基于材料的骨内植入物生物膜感染治疗策略

IF 2.3 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2024-06-30 DOI:10.1016/j.bbrep.2024.101764

Zhuoer Pan , Chengxin Dai , Weixu Li

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引用次数: 0

摘要

植入物相关感染是骨科医生面临的一个重大临床障碍，细菌生物膜的形成是此类感染发生、发展和管理的关键因素。事实证明，传统方法不足以完全根除与生物膜相关的感染。因此，以材料为基础的新型治疗策略应运而生，包括利用抗菌剂、输送载体和协同抗菌系统。在这篇综述中，我们简要概述了抗生物膜策略的最新进展，旨在提供有助于治疗骨内植入物感染的见解。

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Material-based treatment strategies against intraosseous implant biofilm infection

Implant-associated infections present a significant clinical obstacle for orthopedic practitioners, with bacterial biofilm formation serving as a pivotal factor in the initiation, progression, and management of such infections. Conventional approaches have proven inadequate in fully eradicating biofilm-related infections. Consequently, novel material-based therapeutic strategies have been developed, encompassing the utilization of antimicrobial agents, delivery vehicles, and synergistic antibacterial systems. In this review, we provide a succinct overview of recent advancements in anti-biofilm strategies, with the aim of offering insights that may aid in the treatment of intraosseous implant infections.

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.