Yufei Liao, Ping Wang, Ruirui Zhang, Geyu Chen, Jiale Fu
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引用次数: 0
摘要
天麻是一种传统中药材，与生姜一起加工可增强其治疗功效。本研究利用电化学指纹图谱技术和高效液相色谱法（HPLC）研究了生姜加工对天麻质量控制的影响。对电化学指纹图谱条件进行了优化，并比较了生姜和生姜加工样品的指纹图谱。高效液相色谱分析显示，加工后的生姜样品中胃蛋白、姜黄素 A 和姜黄素 B 的含量发生了显著变化。电化学指纹图谱显示生姜和生姜加工样品之间存在明显差异，后者的批次间一致性有所提高。主成分分析和分层聚类分析证明了电化学指纹图谱与高效液相色谱分析结果之间的相关性。研究结果凸显了电化学指纹图谱技术作为高效液相色谱综合质量评估工具的潜力。这项研究为制定 G. elata 的标准化加工方案和质量控制策略提供了宝贵的见解，强调了结合多种分析技术以确保中药材的一致性、安全性和有效性的重要性。
Investigation of quality control of Gastrodia elata using electrochemical fingerprint technology
Gastrodia elata, a traditional Chinese medicinal herb, undergoes processing with ginger to enhance its therapeutic properties. This study investigated the impact of ginger processing on the quality control of G. elata using electrochemical fingerprint technology and high-performance liquid chromatography (HPLC). The electrochemical fingerprint conditions were optimized, and the fingerprints of raw and ginger-processed G. elata samples were compared. The HPLC analysis revealed significant changes in the contents of gastrodin, parishin A, and parishin B after processing. The electrochemical fingerprints exhibited distinct differences between raw and ginger-processed samples, with improved batch-to-batch consistency in the latter. Principal component analysis and hierarchical cluster analysis demonstrated the correlation between the electrochemical fingerprints and HPLC results. The findings highlight the potential of electrochemical fingerprint technology as a complementary tool to HPLC for the comprehensive quality assessment of G. elata. This study provides valuable insights into establishing standardized processing protocols and quality control strategies for G. elata, emphasizing the importance of combining multiple analytical techniques for ensuring the consistency, safety, and efficacy of herbal medicines.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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