基于 rs-fMRI 的成人失神性癫痫神经影像标记

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Epilepsy Research Pub Date : 2024-06-28 DOI:10.1016/j.eplepsyres.2024.107400

Ruoshi Liu , Guozhong Zhu , Yujun Gao , Dongbin Li

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引用次数: 0

摘要

目的约有 20%-30% 的癫痫患者在常规磁共振成像检查中出现阴性结果，这种情况被称为非失神性癫痫。失神性癫痫（AE）是非失神性癫痫的一种常见形式。本研究旨在探讨通过支持向量机（SVM）方法评估的区域同质性（ReHo）对识别失神性癫痫的临床诊断效用。所有参与者均采用静息态功能磁共振成像采集数据。结果与健康对照组相比，AE 患者双侧丘脑的 ReHo 值明显升高，同时双侧丘脑的 ReHo 值降低。根据rs-fMRI数据，SVM被用来区分AE患者和健康对照者。结果表明，双侧普区和丘脑的ReHo值改变可作为AE的神经影像标记，为AE的诊断提供客观指导。

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An rs-fMRI based neuroimaging marker for adult absence epilepsy

Objective

Approximately 20–30 % of epilepsy patients exhibit negative findings on routine magnetic resonance imaging, and this condition is known as nonlesional epilepsy. Absence epilepsy (AE) is a prevalent form of nonlesional epilepsy. This study aimed to investigate the clinical diagnostic utility of regional homogeneity (ReHo) assessed through the support vector machine (SVM) approach for identifying AE.

Methods

This research involved 102 healthy individuals and 93 AE patients. Resting-state functional magnetic resonance imaging was employed for data acquisition in all participants. ReHo analysis, coupled with SVM methodology, was utilized for data processing.

Results

Compared to healthy control individuals, AE patients demonstrated significantly elevated ReHo values in the bilateral putamen, accompanied by decreased ReHo in the bilateral thalamus. SVM was used to differentiate patients with AE from healthy control individuals based on rs-fMRI data. A composite assessment of altered ReHo in the left putamen and left thalamus yielded the highest accuracy at 81.64 %, with a sensitivity of 95.41 % and a specificity of 69.23 %.

Significance

According to the results, altered ReHo values in the bilateral putamen and thalamus could serve as neuroimaging markers for AE, offering objective guidance for its diagnosis.

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来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.