Li-Qing Su , Meng-Xue Li , Li-Yan Gu , Lei Jia , Jie Zhang , Wen-Yue Dou , Jian Chang
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This systematic review aims to evaluate the effectiveness of preoperative ONS on clinical outcomes of patients undergoing colorectal cancer surgery.</p></div><div><h3>Methods</h3><p>Nine databases, including English databases (PubMed, Embase, the Cochrane Library, Web of Science, CINAHL) and Chinese databases (China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, China Science and Technology Journal Database, China Biology Medicine disc), were searched from their establishment to October 2022. The last search was conducted in June 2023, and the language was limited to Chinese and English. The secondary outcomes included wound infection, anastomotic leakage, and length of hospital stay. A meta-analysis was performed using RevMan 5.4 software.</p></div><div><h3>Results</h3><p>Seven randomized controlled trials involving 737 subjects were included, 363 in the treatment group and 374 in the control group. All seven trials involved patients with colorectal cancer. Patients in the intervention group received ONS, while those in the control group received a conventional diet or an isoenergetic and isonitrogenous diet. The fixed effect model showed that the total incidence of postoperative complications in the intervention group was significantly lower than that in the control group [RR=0.83, 95%CI (0.70, 0.98), P=0.03, I<sup>2</sup>=29%, n=737]. However, there was no statistical significance in reducing wound infection, anastomotic leakage, or urinary tract infection.</p></div><div><h3>Conclusion</h3><p>This study provides evidence that preoperative ONS can reduce the incidence of postoperative complications, but there is still a need for further research to support their routine use as preoperative nutritional support.</p></div>","PeriodicalId":36134,"journal":{"name":"Clinical Nutrition Open Science","volume":"56 ","pages":"Pages 152-165"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667268524000524/pdfft?md5=78e3dee3a753c7764eddcbe7dc518b65&pid=1-s2.0-S2667268524000524-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Effectiveness of preoperative oral nutritional supplements in colorectal cancer patients undergoing surgery: A systematic review and meta analysis\",\"authors\":\"Li-Qing Su , Meng-Xue Li , Li-Yan Gu , Lei Jia , Jie Zhang , Wen-Yue Dou , Jian Chang\",\"doi\":\"10.1016/j.nutos.2024.06.002\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background & aims</h3><p>Poor nutritional status has been shown to have a detrimental effect on the prognosis of patients undergoing surgery. Oral nutritional supplements (ONS) are commonly used in the preoperative period to improve the nutritional status of patients. However, the impact of ONS on postoperative clinical outcomes remains controversial. This systematic review aims to evaluate the effectiveness of preoperative ONS on clinical outcomes of patients undergoing colorectal cancer surgery.</p></div><div><h3>Methods</h3><p>Nine databases, including English databases (PubMed, Embase, the Cochrane Library, Web of Science, CINAHL) and Chinese databases (China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, China Science and Technology Journal Database, China Biology Medicine disc), were searched from their establishment to October 2022. The last search was conducted in June 2023, and the language was limited to Chinese and English. The secondary outcomes included wound infection, anastomotic leakage, and length of hospital stay. 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引用次数: 0
摘要
背景与ampamp; 目的营养状况不良已被证明会对手术患者的预后产生不利影响。口服营养补充剂（ONS）通常用于术前，以改善患者的营养状况。然而，口服营养补充剂对术后临床预后的影响仍存在争议。方法检索了9个数据库，包括英文数据库（PubMed、Embase、the Cochrane Library、Web of Science、CINAHL）和中文数据库（中国知网（CNKI）、万方数据知识服务平台、中国科技期刊数据库、中国生物医学文献数据库），检索时间从数据库建立到2022年10月。最后一次检索于 2023 年 6 月进行，检索语言限于中文和英文。次要结果包括伤口感染、吻合口漏和住院时间。结果纳入了 7 项随机对照试验，涉及 737 名受试者，其中治疗组 363 人，对照组 374 人。所有七项试验均涉及结直肠癌患者。干预组患者接受 ONS 治疗，对照组患者接受常规饮食或等能量、等氮饮食。固定效应模型显示，干预组的术后并发症总发生率明显低于对照组[RR=0.83，95%CI（0.70，0.98），P=0.03，I2=29%，n=737]。结论：本研究提供的证据表明，术前 ONS 可降低术后并发症的发生率，但仍需进一步研究以支持其作为术前营养支持的常规应用。
Effectiveness of preoperative oral nutritional supplements in colorectal cancer patients undergoing surgery: A systematic review and meta analysis
Background & aims
Poor nutritional status has been shown to have a detrimental effect on the prognosis of patients undergoing surgery. Oral nutritional supplements (ONS) are commonly used in the preoperative period to improve the nutritional status of patients. However, the impact of ONS on postoperative clinical outcomes remains controversial. This systematic review aims to evaluate the effectiveness of preoperative ONS on clinical outcomes of patients undergoing colorectal cancer surgery.
Methods
Nine databases, including English databases (PubMed, Embase, the Cochrane Library, Web of Science, CINAHL) and Chinese databases (China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, China Science and Technology Journal Database, China Biology Medicine disc), were searched from their establishment to October 2022. The last search was conducted in June 2023, and the language was limited to Chinese and English. The secondary outcomes included wound infection, anastomotic leakage, and length of hospital stay. A meta-analysis was performed using RevMan 5.4 software.
Results
Seven randomized controlled trials involving 737 subjects were included, 363 in the treatment group and 374 in the control group. All seven trials involved patients with colorectal cancer. Patients in the intervention group received ONS, while those in the control group received a conventional diet or an isoenergetic and isonitrogenous diet. The fixed effect model showed that the total incidence of postoperative complications in the intervention group was significantly lower than that in the control group [RR=0.83, 95%CI (0.70, 0.98), P=0.03, I2=29%, n=737]. However, there was no statistical significance in reducing wound infection, anastomotic leakage, or urinary tract infection.
Conclusion
This study provides evidence that preoperative ONS can reduce the incidence of postoperative complications, but there is still a need for further research to support their routine use as preoperative nutritional support.
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