过度饮酒患者独特的尿液和血清代谢组特征:一项探索性研究

IF 3 Q2 SUBSTANCE ABUSE
Zhihong Yang, Hui Gao, Jing Ma, Nathan A. Liang, Sophia P. Liang, Nazmul Huda, Yanchao Jiang, Themis Thoudam, Wanzhu Tu, Jing Su, Maggie Hesler, Kristina Chandler, Suthat Liangpunsakul
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引用次数: 0

摘要

背景:过度饮酒会对人体的代谢途径和器官系统产生多方面的影响。本研究的目的是描述总体代谢组学变化的特征,并确定过度饮酒者体内发生改变的特定途径:这项探索性研究包括 22 名无过度饮酒史的健康对照者和 38 名被确认为过度饮酒的患者。结果:我们发现尿液和血清中的酒精浓度发生了显著变化:我们发现过量饮酒者的尿液和血清代谢物发生了明显变化,影响了各种代谢途径,包括脂质、氨基酸和肽、辅因子和维生素、碳水化合物和核苷酸的代谢。在过量饮酒者的血清和尿液样本中,两种类固醇激素--5-α-雄甾烷-3beta,17beta-二醇二硫酸盐和雄烯二醇(3beta,17beta)二硫酸盐的含量都明显较高。这些水平的升高可能与过量饮酒者发生肝纤维化的风险较高有关:结论:饮酒导致多种代谢途径发生明显改变,凸显了酒精对各种组织和器官系统的系统性影响。这些发现为今后旨在阐明酒精诱导的这些代谢途径的变化及其影响的机理研究奠定了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Unique urine and serum metabolomic signature in patients with excessive alcohol use: An exploratory study

Unique urine and serum metabolomic signature in patients with excessive alcohol use: An exploratory study

Unique urine and serum metabolomic signature in patients with excessive alcohol use: An exploratory study

Background

Excessive alcohol consumption has a multifaceted impact on the body's metabolic pathways and organ systems. The objectives of this study were to characterize global metabolomic changes and identify specific pathways that are altered in individuals with excessive alcohol use.

Methods

This exploratory study included 22 healthy controls with no known history of excessive alcohol use and 38 patients identified as using alcohol excessively. A Fibrosis-4 score was used to determine the risk of underlying alcohol-associated liver disease among the excessive drinkers.

Results

We found significantly altered urinary and serum metabolites among excessive drinkers, affecting various metabolic pathways including the metabolism of lipids, amino acids and peptides, cofactors and vitamins, carbohydrates, and nucleotides. Levels of two steroid hormones—5alpha-androstan-3beta,17beta-diol disulfate and androstenediol (3beta,17beta) disulfate—were significantly higher in both the serum and urine samples of excessive drinkers. These elevated levels may be associated with a higher risk of liver fibrosis in individuals with excessive alcohol use.

Conclusion

Alcohol consumption leads to marked alterations in multiple metabolic pathways, highlighting the systemic impact of alcohol on various tissues and organ systems. These findings provide a foundation for future mechanistic studies aimed at elucidating alcohol-induced changes in these metabolic pathways and their implications.

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