Tara S Davis, Theresa A Koleck, Margaret Q Rosenzweig, Christine Miaskowski, Kirk I Erickson, Susan M Sereika, Catherine M Bender, Yvette P Conley
{"title":"早期乳腺癌妇女核因子 E2 相关因子 2 抗氧化反应元件通路中的基因与癌症相关疲劳之间的关系","authors":"Tara S Davis, Theresa A Koleck, Margaret Q Rosenzweig, Christine Miaskowski, Kirk I Erickson, Susan M Sereika, Catherine M Bender, Yvette P Conley","doi":"10.1188/24.ONF.404-416","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To explore genes in the nuclear factor E2-related factor 2 antioxidative response elements (Nrf2-ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor-positive breast cancer.</p><p><strong>Sample & setting: </strong>Postmenopausal women (N = 116) with early-stage hormone receptor-positive breast cancer were recruited from western Pennsylvania.</p><p><strong>Methods & variables: </strong>Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity.</p><p><strong>Results: </strong>The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity.</p><p><strong>Implications for nursing: </strong>Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions.</p>","PeriodicalId":19549,"journal":{"name":"Oncology nursing forum","volume":"51 4","pages":"404-416"},"PeriodicalIF":1.6000,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association Between Genes in the Nuclear Factor E2-Related Factor 2 Antioxidative Response Elements Pathway and Cancer-Related Fatigue in Women With Early-Stage Breast Cancer.\",\"authors\":\"Tara S Davis, Theresa A Koleck, Margaret Q Rosenzweig, Christine Miaskowski, Kirk I Erickson, Susan M Sereika, Catherine M Bender, Yvette P Conley\",\"doi\":\"10.1188/24.ONF.404-416\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>To explore genes in the nuclear factor E2-related factor 2 antioxidative response elements (Nrf2-ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor-positive breast cancer.</p><p><strong>Sample & setting: </strong>Postmenopausal women (N = 116) with early-stage hormone receptor-positive breast cancer were recruited from western Pennsylvania.</p><p><strong>Methods & variables: </strong>Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity.</p><p><strong>Results: </strong>The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity.</p><p><strong>Implications for nursing: </strong>Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions.</p>\",\"PeriodicalId\":19549,\"journal\":{\"name\":\"Oncology nursing forum\",\"volume\":\"51 4\",\"pages\":\"404-416\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-06-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oncology nursing forum\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1188/24.ONF.404-416\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"NURSING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncology nursing forum","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1188/24.ONF.404-416","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NURSING","Score":null,"Total":0}
Association Between Genes in the Nuclear Factor E2-Related Factor 2 Antioxidative Response Elements Pathway and Cancer-Related Fatigue in Women With Early-Stage Breast Cancer.
Objectives: To explore genes in the nuclear factor E2-related factor 2 antioxidative response elements (Nrf2-ARE) signaling pathway using a multiomics approach for associations with variability of cancer-related fatigue (CRF) in postmenopausal women with early-stage hormone receptor-positive breast cancer.
Sample & setting: Postmenopausal women (N = 116) with early-stage hormone receptor-positive breast cancer were recruited from western Pennsylvania.
Methods & variables: Candidate genes from the Nrf2-ARE pathway were investigated for associations with CRF occurrence and severity. Associations were evaluated using logistic regression for occurrence and linear regression for severity.
Results: The rs2706110 TT genotype in NFE2L2 was associated with a 3.5-fold increase in odds of CRF occurrence. The cytosine-phosphate-guanine (CpG) site cg22820568 in PRDX1 was associated with CRF occurrence and severity.
Implications for nursing: Biomarkers based on Nrf2-ARE genes may help to identify women at increased risk for more severe CRF and to develop targeted interventions.
期刊介绍：
The mission of the Oncology Nursing Forum, an official publication of ONS, is to
Convey research information related to practice, technology, education, and leadership.
Disseminate oncology nursing research and evidence-based practice to enhance transdisciplinary quality cancer care.
Stimulate discussion of critical issues relevant to oncology nursing.
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