精神神经症状群及其与乳腺癌基因组不稳定性的关系

IF 1.6 4区医学 Q2 NURSING

Oncology nursing forum Pub Date : 2024-06-14 DOI:10.1188/24.ONF.391-403

Susan C Grayson, Susan M Sereika, Yvette P Conley, Adrian V Lee, Steffi Oesterreich, Theresa A Koleck, Margaret Q Rosenzweig, Tiantong Liu, Susan W Wesmiller

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引用次数: 0

摘要

目标：对转移性乳腺癌患者的精神神经症状群进行表型分析，并将这些表型与个体特征和来自循环肿瘤 DNA 的癌症基因组变量联系起来：对转移性乳腺癌患者的精神神经症状群（PN）进行表型，并将这些表型与循环肿瘤DNA中的个体特征和癌症基因组变量联系起来：本研究包括在宾夕法尼亚州西部招募的 201 名转移性乳腺癌患者：采用描述性横断面设计。症状数据通过 MD 安德森症状量表收集，癌症基因组数据通过对参与者血液中的循环肿瘤 DNA 进行超低通量全基因组测序收集：结果：在转移性乳腺癌患者中发现了三种不同的 PN 症状表型：轻度症状、中度症状和严重的情绪相关症状。乳腺癌 TP53 基因缺失与中度至重度症状表型显著相关（p = 0.013）：对护理工作的启示：与基因组不稳定性增加相关的特定癌症基因组变化可能是 PN 症状的预测因素。这一发现可能有助于积极治疗或揭示症状控制的新治疗靶点。

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The Psychoneurologic Symptom Cluster and Its Association With Breast Cancer Genomic Instability.

Objectives: To phenotype the psychoneurologic (PN) symptom cluster in individuals with metastatic breast cancer and associate those phenotypes with individual characteristics and cancer genomic variables from circulating tumor DNA.

Sample & setting: This study included 201 individuals with metastatic breast cancer recruited in western Pennsylvania.

Methods & variables: A descriptive, cross-sectional design was used. Symptom data were collected via the MD Anderson Symptom Inventory, and cancer genomic data were collected via ultra-low-pass whole-genome sequencing of circulating tumor DNA from participant blood.

Results: Three distinct PN symptom phenotypes were described in a population with metastatic breast cancer: mild symptoms, moderate symptoms, and severe mood-related symptoms. Breast cancer TP53 deletion was significantly associated with membership in a moderate to severe symptoms phenotype (p = 0.013).

Implications for nursing: Specific cancer genomic changes associated with increased genomic instability may be predictive of PN symptoms. This finding may enable proactive treatment or reveal new therapeutic targets for symptom management.

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来源期刊

Oncology nursing forum 医学-护理

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： The mission of the Oncology Nursing Forum, an official publication of ONS, is to Convey research information related to practice, technology, education, and leadership. Disseminate oncology nursing research and evidence-based practice to enhance transdisciplinary quality cancer care. Stimulate discussion of critical issues relevant to oncology nursing.