芒果叶提取物中的一种成分芒果苷能抑制人体皮脂细胞的脂质合成。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-07-01 DOI:10.1080/10286020.2024.2369279

Da-Min Jung, Sangsoo Lee, Eun-Mi Kim, Chong Won Choi, Kee K Kim

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引用次数: 0

摘要

抑制皮脂细胞的脂质合成是治疗痤疮的关键。天然产物衍生物质对脂质合成的影响尚不清楚。本研究调查了莽草叶水提取物（WEML）对人体皮脂细胞脂质合成的影响。皮脂腺细胞在低血清条件下分化会增加脂质积累和增殖激活受体γ的表达。WEML 处理可明显抑制皮脂腺细胞中的脂质积累和脂肪生成 mRNA 的表达。WEML 中的生物活性化合物芒果苷也能通过 AKT 途径减少脂质积累和成脂 mRNA 的表达。因此，WEML 和芒果苷能有效抑制皮脂细胞中脂质的合成，有望用于痤疮的治疗。

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Mangiferin, a component of Mangifera indica leaf extracts, inhibits lipid synthesis in human sebocytes.

Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of Mangifera indica leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.