伊朗设拉子 10 年间新生儿极端高胆红素血症的交换输血趋势和风险因素。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Fariba Hemmati, Seyed Moein Mahini, Mehrnoosh Bushehri, Amir Hossein Asadi, Hamide Barzegar
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引用次数: 0

摘要

背景:交换输血(ET)是治疗急性胆红素脑病和新生儿极度高胆红素血症(ENH)的有效方法。它可以降低死亡率和发病率。本研究旨在调查伊朗住院新生儿需要进行 ET 的 ENH 的趋势和风险因素:方法:2011 年至 2021 年期间,在伊朗设拉子对因 ENH 而接受 ET 的新生儿病历进行了回顾性分析。临床记录用于收集人口统计学和实验室数据。定量数据以均数±SD表示,定性数据以频率和百分比表示。结果:研究期间,为 329 名患者进行了 377 次 ET。在研究期间,每年的 ET 率下降了 71.2%。ENH最常见的风险因素是葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症(35%),其次是早产儿(13.06%)、ABO溶血病(7.6%)、败血症(6.4%)、Rh溶血病(6.08%)和小血型不合(3.34%)。28.52%的病例未找到导致 ENH 的原因。17名(5.1%)新生儿患有急性胆红素脑病,其中6名(35.29%)患有G6PD缺乏症,6名(35.29%)患有ABO血型不合,2名(11.76%)患有Rh血型不合:尽管ET发生率有所下降,但似乎仍有必要考虑不同的风险因素,并应制定适当的指南,以便及早识别和管理有ENH风险的新生儿。研究结果突显了伊朗南部 ENH 的重要风险因素,有助于制定适当的预防策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exchange Transfusion Trends and Risk Factors for Extreme Neonatal Hyperbilirubinemia over 10 Years in Shiraz, Iran.

Background: Exchange transfusion (ET) is an effective treatment for acute bilirubin encephalopathy and extreme neonatal hyperbilirubinemia (ENH). It can reduce mortality and morbidity. This study aimed to investigate the trends and risk factors of ENH requiring ET in hospitalized neonates in Iran.

Methods: A retrospective analysis of medical records of neonates who underwent ET due to ENH was conducted from 2011 to 2021, in Shiraz, Iran. Clinical records were used to gather demographic and laboratory data. The quantitative data were expressed as mean±SD, and qualitative data was presented as frequency and percentage. P<0.05 was considered statistically significant.

Results: During the study, 377 ETs were performed for 329 patients. The annual rate of ET decreased by 71.2% during the study period. The most common risk factor of ENH was glucose-6-phosphate dehydrogenase (G6PD) deficiency (35%), followed by prematurity (13.06%), ABO hemolytic disease (7.6%), sepsis (6.4%), Rh hemolytic disease (6.08%), and minor blood group incompatibility (3.34%). In 28.52% of the cases, the cause of ENH was not identified. 17 (5.1%) neonates had acute bilirubin encephalopathy, of whom 6 (35.29%) had G6PD deficiency, 6 (35.29%) had ABO incompatibility, and 2 (11.76%) had Rh incompatibility.

Conclusion: Although the rate of ET occurrence has decreased, it seems necessary to consider different risk factors and appropriate guidelines for early identification and management of neonates at risk of ENH should be developed. The findings of the study highlighted the important risk factors of ENH in southern Iran, allowing for the development of appropriate prevention strategies.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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