{"title":"头颈癌中 18F-FDG PET/CT 和血液学参数的预后价值","authors":"Risa Wakisaka, Takumi Kumai, Hiroki Komatsuda, Hidekiyo Yamaki, Michihisa Kono, Ryosuke Sato, Kenzo Ohara, Kan Kishibe, Tatsuya Hayashi, Atsutaka Okizaki, Miki Takahara","doi":"10.1111/coa.14195","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Fluorine 18-fluoro-glucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) is commonly used for the staging of head and neck cancer. This study aimed to evaluate the correlation between <sup>18</sup>F-FDG PET/CT, haematological parameters and prognosis in patients with advanced head and neck cancer.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>This was a single-institutional retrospective study of 83 patients with advanced head and neck squamous cell carcinoma (HNSCC) who underwent <sup>18</sup>F-FDG PET/CT imaging before initial treatment between 2014 and 2018. <sup>18</sup>F-FDG PET/CT after treatment was performed in 57 patients. The prognostic parameters of the pre- and post-treatment maximum standardised uptake value (SUV<sub>max</sub>), metabolic tumour volume (MTV), total lesion glycolysis (TLG) of primary tumours and haematological parameters were analysed to evaluate the association between overall survival (OS) and progression-free survival (PFS).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Pre-MTV, pre-TLG and post-SUV<sub>max</sub> were significantly associated with poor OS and PFS (<i>p</i> < 0.05). Haematological parameters, including pretreatment neutrophil/lymphocyte ratio and C-reactive protein/albumin ratio, were associated with <sup>18</sup>F-FDG PET/CT parameters. In multivariate analysis, post-SUV<sub>max</sub> was an independent prognostic factor for OS and PFS.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>A correlation between PET/CT metabolic and haematological parameters was observed. The volume and intensity of <sup>18</sup>F-FDG uptake region, in addition to haematological parameters, are feasible markers for predicting the progression of HNSCC in daily practice. Further, post-SUV<sub>max</sub> could be an independent parameter for predicting poor survival.</p>\n </section>\n </div>","PeriodicalId":10431,"journal":{"name":"Clinical Otolaryngology","volume":"49 6","pages":"733-741"},"PeriodicalIF":1.7000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prognostic Value of the 18F-FDG PET/CT and Haematological Parameters in Head and Neck Cancer\",\"authors\":\"Risa Wakisaka, Takumi Kumai, Hiroki Komatsuda, Hidekiyo Yamaki, Michihisa Kono, Ryosuke Sato, Kenzo Ohara, Kan Kishibe, Tatsuya Hayashi, Atsutaka Okizaki, Miki Takahara\",\"doi\":\"10.1111/coa.14195\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Introduction</h3>\\n \\n <p>Fluorine 18-fluoro-glucose positron emission tomography/computed tomography (<sup>18</sup>F-FDG PET/CT) is commonly used for the staging of head and neck cancer. This study aimed to evaluate the correlation between <sup>18</sup>F-FDG PET/CT, haematological parameters and prognosis in patients with advanced head and neck cancer.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>This was a single-institutional retrospective study of 83 patients with advanced head and neck squamous cell carcinoma (HNSCC) who underwent <sup>18</sup>F-FDG PET/CT imaging before initial treatment between 2014 and 2018. <sup>18</sup>F-FDG PET/CT after treatment was performed in 57 patients. The prognostic parameters of the pre- and post-treatment maximum standardised uptake value (SUV<sub>max</sub>), metabolic tumour volume (MTV), total lesion glycolysis (TLG) of primary tumours and haematological parameters were analysed to evaluate the association between overall survival (OS) and progression-free survival (PFS).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Pre-MTV, pre-TLG and post-SUV<sub>max</sub> were significantly associated with poor OS and PFS (<i>p</i> < 0.05). Haematological parameters, including pretreatment neutrophil/lymphocyte ratio and C-reactive protein/albumin ratio, were associated with <sup>18</sup>F-FDG PET/CT parameters. In multivariate analysis, post-SUV<sub>max</sub> was an independent prognostic factor for OS and PFS.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>A correlation between PET/CT metabolic and haematological parameters was observed. The volume and intensity of <sup>18</sup>F-FDG uptake region, in addition to haematological parameters, are feasible markers for predicting the progression of HNSCC in daily practice. Further, post-SUV<sub>max</sub> could be an independent parameter for predicting poor survival.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10431,\"journal\":{\"name\":\"Clinical Otolaryngology\",\"volume\":\"49 6\",\"pages\":\"733-741\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Otolaryngology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/coa.14195\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OTORHINOLARYNGOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Otolaryngology","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/coa.14195","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
Prognostic Value of the 18F-FDG PET/CT and Haematological Parameters in Head and Neck Cancer
Introduction
Fluorine 18-fluoro-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) is commonly used for the staging of head and neck cancer. This study aimed to evaluate the correlation between 18F-FDG PET/CT, haematological parameters and prognosis in patients with advanced head and neck cancer.
Methods
This was a single-institutional retrospective study of 83 patients with advanced head and neck squamous cell carcinoma (HNSCC) who underwent 18F-FDG PET/CT imaging before initial treatment between 2014 and 2018. 18F-FDG PET/CT after treatment was performed in 57 patients. The prognostic parameters of the pre- and post-treatment maximum standardised uptake value (SUVmax), metabolic tumour volume (MTV), total lesion glycolysis (TLG) of primary tumours and haematological parameters were analysed to evaluate the association between overall survival (OS) and progression-free survival (PFS).
Results
Pre-MTV, pre-TLG and post-SUVmax were significantly associated with poor OS and PFS (p < 0.05). Haematological parameters, including pretreatment neutrophil/lymphocyte ratio and C-reactive protein/albumin ratio, were associated with 18F-FDG PET/CT parameters. In multivariate analysis, post-SUVmax was an independent prognostic factor for OS and PFS.
Conclusion
A correlation between PET/CT metabolic and haematological parameters was observed. The volume and intensity of 18F-FDG uptake region, in addition to haematological parameters, are feasible markers for predicting the progression of HNSCC in daily practice. Further, post-SUVmax could be an independent parameter for predicting poor survival.
期刊介绍：
Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with:
current otorhinolaryngological practice
audiology, otology, balance, rhinology, larynx, voice and paediatric ORL
head and neck oncology
head and neck plastic and reconstructive surgery
continuing medical education and ORL training
The emphasis is on high quality new work in the clinical field and on fresh, original research.
Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject.
• Negative/null results
In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.
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