塞马鲁肽对Wistar白化大鼠多柔比星诱发的心脏毒性的影响

IF 2.5 4区 医学 Q3 ONCOLOGY
Cancer Management and Research Pub Date : 2024-06-27 eCollection Date: 2024-01-01 DOI:10.2147/CMAR.S468453
Raz Muhammed HamaSalih
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引用次数: 0

摘要

背景:多柔比星(DOX多柔比星(DOX)用于治疗各种癌症。然而,其使用受到心脏毒性的限制,而心脏毒性是发病和死亡的主要原因。目的:本研究旨在确定不同剂量的塞马鲁肽(SEM)对大鼠模型中 DOX 诱导的心脏毒性的保护作用:将 35 只雌性 Wistar 大鼠分为 5 组。第一组接受蒸馏水作为阴性对照(NC);阳性对照(PC)组接受蒸馏水加 DOX;第三组(SL)接受低剂量 SEM(0.06 mg/kg)加 DOX;第四组(SM)接受中等剂量 SEM(0.12 mg/kg)加 DOX;第五组(SH)接受高剂量 SEM(0.24 mg/kg)加 DOX。第8天采集血样,评估血清肌钙蛋白、乳酸脱氢酶(LDH)、肌酸磷酸激酶(CPK)、总脂质和血管细胞粘附分子1(VCAM-1)。心脏组织被送去进行组织病理学分析:结果:DOX增加了总胆固醇(TC)、低密度脂蛋白(LDL)、甘油三酯(TG)、LDH和CKP水平。中等剂量和高剂量的塞马鲁肽分别显著降低了血清胆固醇水平(*p = 0.0199)和(**p = 0.0077)。使用 SEM 治疗后,SL 组的总重量明显降低(***p = 0.0013),SM 组和 SH 组的总重量也有非常明显的降低(****p < 0.0001)。所有剂量的 SEM 都能降低 CPK 水平。SL组的肌钙蛋白水平明显下降(*p=0.0344)。三种剂量的 SEM 均降低了血清 LDH 水平。组织病理学结果支持生化结果:结论:在大鼠模型中,塞马鲁肽可通过降低血清中心脏毒性的生化指标,对DOX诱导的心脏毒性具有保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of Semaglutide in Doxorubicin-Induced Cardiac Toxicity in Wistar Albino Rats.

Background: Doxorubicin (DOX) is used to treat various types of cancers. However, its use is restricted by cardiotoxicity, a leading cause of morbidity and mortality. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) may be associated with cardioprotective properties.

Purpose: This study aims to determine the protective effects of different semaglutide (SEM) doses on DOX-induced cardiotoxicity in a rat model.

Methodology: Thirty-five female Wistar rats were divided into five groups. The first group received distilled water as a negative control (NC); the positive control (PC) group received distilled water plus DOX; the third group (SL) received a low dose of SEM (0.06 mg/kg) plus DOX; the fourth group (SM) received a moderate dose of SEM (0.12 mg/kg) plus DOX; and the fifth group (SH) received a high dose of SEM (0.24 mg/kg) plus DOX. Blood samples were collected on day 8 to assess serum troponin, lactate dehydrogenase (LDH), creatine phosphokinase (CPK), total lipid profile, and vascular cell adhesion molecule 1 (VCAM-1). Cardiac tissue was sent for histopathological analysis.

Results: DOX increased the total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), LDH, and CKP levels. Moderate and high doses of semaglutide significantly reduced serum cholesterol levels (*p = 0.0199), (**p = 0.0077), respectively. A significant reduction (***p = 0.0013) in total body weight after treatment with SEM was observed in the SL group and a highly significant reduction (****p < 0.0001) was observed in the SM and SH groups. SEM at all doses reduced CPK levels. The SL group showed a significant reduction in troponin level (*p=0.0344). Serum LDH levels were reduced by all three SEM doses. The histopathological findings support the biochemical results.

Conclusion: Semaglutide may possess cardioprotective properties against DOX-induced cardiotoxicity in a rat model by decreasing serum biochemical markers of cardiotoxicity.

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来源期刊
Cancer Management and Research
Cancer Management and Research Medicine-Oncology
CiteScore
7.40
自引率
0.00%
发文量
448
审稿时长
16 weeks
期刊介绍: Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.
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