用于早期癌症检测的太赫兹生物医学传感：带旋转分环谐振器的超材料石墨烯生物传感器

IF 2.1 4区工程技术 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC

IEEE Photonics Journal Pub Date : 2024-06-12 DOI:10.1109/JPHOT.2024.3413528

Marwa Rezeg;Aymen Hlali;Hassen Zairi

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引用次数: 0

摘要

本文提出并分析了一种用于早期癌症检测的高灵敏度石墨烯基超材料生物传感器。该传感器设计采用了三个环形石墨烯分裂环谐振器，以实现对偏振不敏感的性能。有限元法模拟结果证实，所设计的生物传感器具有可调的传感能力。被测材料覆盖了生物传感器的表面，共振发生时会产生高吸收。传感器的共振频率取决于分析物样本的光学特性，从而使该装置能够区分各种癌细胞类型，包括皮肤癌、血癌、宫颈癌、肾上腺癌和乳腺癌。利用石墨烯的可调性研究化学势、弛豫时间和温度的影响，目的是最大限度地提高传感器的灵敏度。所设计的生物传感器能检测折射率的变化，对健康和癌症细胞样本的最大灵敏度为 3.880 THz/RUI，Q 因子为 8.948，优点系数为 8.146 RUI$^{-1}$。我们对拟议生物传感器的电场和磁场空间模式、表面电流分布和功率流进行了深入分析，以确保其灵敏度和生物医学应用的适用性。研究结果证明了太赫兹传感器在早期癌症检测方面的潜力。

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THz Biomedical Sensing for Early Cancer Detection: Metamaterial Graphene Biosensors With Rotated Split-Ring Resonators

A highly sensitive graphene-based metamaterial biosensor is proposed and analyzed for early cancer detection. The sensor design employs three circular graphene split ring resonators to achieve polarization-insensitive performance. The finite element method simulation results confirm that the designed biosensor exhibits a tunable sensing capability. The material under test covers the surface of the biosensor, where resonance occurs with high absorption. The resonance frequencies of the sensor are dependent on the optical properties of the analyte sample, enabling the device to differentiate between various cancer cell types, including skin, blood, cervical, adrenal gland, and breast cancer. Graphene's tunability is leveraged to study the effects of chemical potential, relaxation time, and temperature, with the aim of maximizing the sensor's sensitivity. The designed biosensor, which detects variations in refractive index, exhibits a maximum sensitivity of 3.880 THz/RUI, a Q-factor of 8.948, and a figure-of-merit of 8.146 RUI

$^{-1}$

for healthy and cancerous cell samples. The spatial patterns of electric and magnetic fields, surface current distribution, and power flow of the proposed biosensor have been thoroughly analyzed to ensure its sensitivity and suitability for biomedical applications. The results demonstrate the potential of the THz sensor for early cancer detection.

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来源期刊

IEEE Photonics Journal ENGINEERING, ELECTRICAL & ELECTRONIC-OPTICS

CiteScore

4.50

自引率

8.30%

发文量

489

审稿时长

1.4 months

期刊介绍： Breakthroughs in the generation of light and in its control and utilization have given rise to the field of Photonics, a rapidly expanding area of science and technology with major technological and economic impact. Photonics integrates quantum electronics and optics to accelerate progress in the generation of novel photon sources and in their utilization in emerging applications at the micro and nano scales spanning from the far-infrared/THz to the x-ray region of the electromagnetic spectrum. IEEE Photonics Journal is an online-only journal dedicated to the rapid disclosure of top-quality peer-reviewed research at the forefront of all areas of photonics. Contributions addressing issues ranging from fundamental understanding to emerging technologies and applications are within the scope of the Journal. The Journal includes topics in: Photon sources from far infrared to X-rays, Photonics materials and engineered photonic structures, Integrated optics and optoelectronic, Ultrafast, attosecond, high field and short wavelength photonics, Biophotonics, including DNA photonics, Nanophotonics, Magnetophotonics, Fundamentals of light propagation and interaction; nonlinear effects, Optical data storage, Fiber optics and optical communications devices, systems, and technologies, Micro Opto Electro Mechanical Systems (MOEMS), Microwave photonics, Optical Sensors.