Carolyn Fall, Rebecca Baer, Henry Lee, Christina Chambers, Gretchen Bandoli
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引用次数: 0
摘要
研究目的评估加利福尼亚州缺氧缺血性脑病（HIE）婴儿管理和预后的变化：研究设计：使用 ICD 编码从加利福尼亚行政出生队列中识别 HIE 婴儿，并将其分为两个时代：时代 1（2010-2015 年）和时代 2（2016-2019 年）。采用对数线性回归法计算了每个时代治疗性低温（TH）的风险比（RR）及其结果：在该队列中，共发现了 4779 例 HIE 婴儿。加利福尼亚州的 HIE 发病率逐年增加，从 0.5/1,000 例加利福尼亚州新生儿增加到 2018 年的峰值 1.5/1,000 例新生儿。与第一纪元相比，第二纪元对轻度 HIE 婴儿使用 TH 的情况有所增加。不同时期接受TH治疗的轻度HIE婴儿的结果没有明显差异：自2015年以来，加利福尼亚州接受TH治疗的轻度HIE婴儿明显增多，但这些患者的治疗效果没有发现差异。
Changes in the Treatment and Outcomes of Different Severities of Neonatal Hypoxic Ischemic Encephalopathy in California: A Retrospective Cohort Study.
Objective: Evaluate the changes in management and outcomes of Californian infants with hypoxic ischemic encephalopathy (HIE).
Study design: Infants with HIE were identified from a California administrative birth cohort using ICD codes and divided into two epochs, Epoch 1 (2010-2015) and Epoch 2 (2016-2019). Risk ratios (RR) for therapeutic hypothermia (TH) in each epoch and their outcomes were calculated using log-linear regression.
Results: In this cohort, 4779 infants with HIE were identified. Incidence of HIE in California increased yearly from 0.5/1,000 California births to a peak of 1.5/1,000 births in 2018. The use of TH in infants with mild HIE increased in Epoch 2 compared to Epoch 1. There was no significant difference in outcomes between epochs for infants with mild HIE that received TH.
Conclusion: Significantly more infants with mild HIE received TH since 2015 in California, but no difference in outcomes was found for these patients.
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