腹侧纹状体对社会奖赏的反应迟钝与精神病患者更严重的动机和愉悦感缺失有关。

Jack Blanchard, Alexander Shackman, Jason Smith, Ryan Orth, Christina Savage, Paige Didier, Julie McCarthy, Melanie Bennett
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引用次数: 0

摘要

在患有精神障碍的患者中,社交障碍是一种常见的、使人衰弱和难以治疗的疾病。虽然这种障碍的根源无疑是复杂的,但汇集在一起的证据表明,社交动机和愉悦(MAP)缺陷起着关键作用。然而,大多数神经影像学研究都集中在金钱奖励方面,因此无法得出决定性的推论。在这里,我们利用平行的社交和货币奖励延迟fMRI范式,在一个富含精神病的跨诊断样本中,测试腹侧纹状体(介导食欲动机和享乐的分布式神经回路的关键组成部分)对社交奖励的反应性减弱是否与更严重的MAP症状有关。为了最大限度地提高生态有效性和转化相关性,我们利用了已建立社交关系的伙伴表达积极反馈的自然视听片段。虽然这两种范式都能强烈刺激腹侧纹状体,但只有对社交激励的反应性与临床医生评定的 MAP 缺陷有关。在控制了其他症状、二元诊断状态或腹侧纹状体对金钱激励的反应性后,这种关联性仍然很明显。后续分析表明,这种关联主要反映了在接受社交奖励时纹状体激活的减弱。这些观察结果提供了一个以神经生物学为基础的框架,用于概念化许多精神病患者的社交失调症状和社交障碍,并强调了制定有针对性的干预策略的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Blunted ventral striatal reactivity to social reward is associated with more severe motivation and pleasure deficits in psychosis.

Among individuals living with psychotic disorders, social impairment is common, debilitating, and challenging to treat. While the roots of this impairment are undoubtedly complex, converging lines of evidence suggest that social motivation and pleasure (MAP) deficits play a key role. Yet most neuroimaging studies have focused on monetary rewards, precluding decisive inferences. Here we leveraged parallel social and monetary incentive delay fMRI paradigms to test whether blunted reactivity to social incentives in the ventral striatum-a key component of the distributed neural circuit mediating appetitive motivation and hedonic pleasure-is associated with more severe MAP symptoms in a transdiagnostic sample enriched for psychosis. To maximize ecological validity and translational relevance, we capitalized on naturalistic audiovisual clips of an established social partner expressing positive feedback. Although both paradigms robustly engaged the ventral striatum, only reactivity to social incentives was associated with clinician-rated MAP deficits. This association remained significant when controlling for other symptoms, binary diagnostic status, or ventral striatum reactivity to monetary incentives. Follow-up analyses suggested that this association predominantly reflects diminished striatal activation during the receipt of social reward. These observations provide a neurobiologically grounded framework for conceptualizing the social-anhedonia symptoms and social impairments that characterize many individuals living with psychotic disorders and underscore the need to establish targeted intervention strategies.

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