{"title":"含有 Melissa officinalis、Pimpinella anisum 和大马士革蔷薇的传统草药配方对便秘为主的肠易激综合征（IBS-C）患者焦虑和抑郁的影响：双盲随机临床试验。","authors":"Maryam Azimi , Hossein Karimi Dokht Shahrbabaki , Mahboobeh Raeiszadeh , Omid Eslami","doi":"10.1016/j.explore.2024.05.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Irritable bowel syndrome (IBS) is associated with a high prevalence of anxiety and depression. This study aimed to evaluate the effects of a traditional Persian herbal formula containing <em>Melissa officinalis, Pimpinella anisum</em>, and <em>Rosa damascena</em> (MPR) on anxiety and depression in IBS patients with symptoms of constipation-predominant IBS (IBS-C).</p></div><div><h3>Methods</h3><p>This double-blind randomized clinical trial was conducted in Afzalipour Hospital via block randomization method. A total of 96 IBS-C patients (based on Rome IV criteria), aged 18–60 years, were included in this study. Participants received capsules containing either 500 mg of herbal formula or placebo (cornstarch) twice a day for four weeks Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale.</p></div><div><h3>Results</h3><p>Forty-three patients in the intervention group and 45 patients in the control group completed this study. Except for the education level, there were no significant differences in the demographic characteristics between the two groups (<em>P</em> > 0.05). The mean levels of anxiety and depression, and total IBS symptom severity score showed no significant differences between the two groups at baseline (<em>P</em> > 0.05). After four weeks of treatment, the anxiety score considerably improvement in the treatment group (Cohen's <em>d</em> = -1.19, 95 % confidence intervals [CIs] -4.49 to 2.13), as did the depression score (Cohen's <em>d</em> = -1.93, 95 % CIs -4.32 to 2.79).</p></div><div><h3>Conclusion</h3><p>MPR considerably improved anxiety and depression in patients with IBS-C compared to the placebo without serious side effects.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of a traditional herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena on anxiety and depression in patients with constipation-predominant irritable bowel syndrome (IBS-C): A double-blind randomized clinical trial\",\"authors\":\"Maryam Azimi , Hossein Karimi Dokht Shahrbabaki , Mahboobeh Raeiszadeh , Omid Eslami\",\"doi\":\"10.1016/j.explore.2024.05.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Irritable bowel syndrome (IBS) is associated with a high prevalence of anxiety and depression. This study aimed to evaluate the effects of a traditional Persian herbal formula containing <em>Melissa officinalis, Pimpinella anisum</em>, and <em>Rosa damascena</em> (MPR) on anxiety and depression in IBS patients with symptoms of constipation-predominant IBS (IBS-C).</p></div><div><h3>Methods</h3><p>This double-blind randomized clinical trial was conducted in Afzalipour Hospital via block randomization method. A total of 96 IBS-C patients (based on Rome IV criteria), aged 18–60 years, were included in this study. Participants received capsules containing either 500 mg of herbal formula or placebo (cornstarch) twice a day for four weeks Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale.</p></div><div><h3>Results</h3><p>Forty-three patients in the intervention group and 45 patients in the control group completed this study. Except for the education level, there were no significant differences in the demographic characteristics between the two groups (<em>P</em> > 0.05). The mean levels of anxiety and depression, and total IBS symptom severity score showed no significant differences between the two groups at baseline (<em>P</em> > 0.05). After four weeks of treatment, the anxiety score considerably improvement in the treatment group (Cohen's <em>d</em> = -1.19, 95 % confidence intervals [CIs] -4.49 to 2.13), as did the depression score (Cohen's <em>d</em> = -1.93, 95 % CIs -4.32 to 2.79).</p></div><div><h3>Conclusion</h3><p>MPR considerably improved anxiety and depression in patients with IBS-C compared to the placebo without serious side effects.</p></div>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2024-05-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1550830724000946\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1550830724000946","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
摘要
简介肠易激综合征（IBS）与高发的焦虑和抑郁有关。本研究旨在评估一种含有 Melissa officinalis、Pimpinella anisum 和大马士革蔷薇（MPR）的传统波斯草药配方对便秘为主的肠易激综合征（IBS-C）患者焦虑和抑郁的影响：这项双盲随机临床试验在阿夫扎利普尔医院通过区组随机法进行。共有 96 名 18-60 岁的 IBS-C 患者（根据罗马 IV 标准）参与了这项研究。参与者服用含有 500 毫克草药配方或安慰剂（玉米淀粉）的胶囊，每天两次，连续服用四周：干预组和对照组分别有 43 名和 45 名患者完成了本研究。除教育程度外，两组患者的人口统计学特征无显著差异（P>0.05）。两组患者的焦虑和抑郁平均水平以及肠易激综合征症状严重程度总分在基线时无明显差异（P>0.05）。治疗四周后，治疗组的焦虑评分明显改善（Cohen's d = -1.19, 95 % 置信区间 [CIs] -4.49 to 2.13），抑郁评分也有所改善（Cohen's d = -1.93, 95 % 置信区间 -4.32 to 2.79）：结论：与安慰剂相比，MPR能显著改善肠易激综合征（IBS-C）患者的焦虑和抑郁状况，且无严重副作用。
Effects of a traditional herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena on anxiety and depression in patients with constipation-predominant irritable bowel syndrome (IBS-C): A double-blind randomized clinical trial
Introduction
Irritable bowel syndrome (IBS) is associated with a high prevalence of anxiety and depression. This study aimed to evaluate the effects of a traditional Persian herbal formula containing Melissa officinalis, Pimpinella anisum, and Rosa damascena (MPR) on anxiety and depression in IBS patients with symptoms of constipation-predominant IBS (IBS-C).
Methods
This double-blind randomized clinical trial was conducted in Afzalipour Hospital via block randomization method. A total of 96 IBS-C patients (based on Rome IV criteria), aged 18–60 years, were included in this study. Participants received capsules containing either 500 mg of herbal formula or placebo (cornstarch) twice a day for four weeks Anxiety and depression were assessed using the Hospital Anxiety and Depression Scale.
Results
Forty-three patients in the intervention group and 45 patients in the control group completed this study. Except for the education level, there were no significant differences in the demographic characteristics between the two groups (P > 0.05). The mean levels of anxiety and depression, and total IBS symptom severity score showed no significant differences between the two groups at baseline (P > 0.05). After four weeks of treatment, the anxiety score considerably improvement in the treatment group (Cohen's d = -1.19, 95 % confidence intervals [CIs] -4.49 to 2.13), as did the depression score (Cohen's d = -1.93, 95 % CIs -4.32 to 2.79).
Conclusion
MPR considerably improved anxiety and depression in patients with IBS-C compared to the placebo without serious side effects.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
