接种 COVID-19 疫苗与焦虑症状的关系:以硬皮病患者为中心的干预网络 (SPIN) 队列纵向研究。

IF 3.5 2区 医学 Q2 PSYCHIATRY
Gabrielle Virgili-Gervais , Richard S. Henry , Linda Kwakkenbos , Marie-Eve Carrier , Scott Patten , Susan J. Bartlett , Luc Mouthon , John Varga , Andrea Benedetti , Brett D. Thombs , the SPIN COVID-19 Patient Advisory Team , SPIN Investigators
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引用次数: 0

摘要

目的:系统性硬化症(SSc)患者的焦虑症状在COVID-19大流行初期有所增加,随后又恢复到大流行前的水平,但这只是一个综合结果,并未评估接种疫苗是否有助于降低焦虑症状水平。我们研究了接种 COVID-19 疫苗是否与系统性硬化症患者焦虑症状的减轻有关:纵向硬皮病患者中心干预网络(SPIN)COVID-19队列于2020年4月启动,包括正在进行的SPIN队列的参与者和外部注册者。参与者在 2020 年 7 月之前每两周完成一次评估,之后每 4 周完成一次评估,直至 2022 年 8 月(32 次评估)。我们使用线性混合模型来评估 PROMIS Anxiety 4a v1.0 焦虑域得分的纵向趋势及其与疫苗接种的关系:在纳入分析的517名参与者中,489人(95%)在2021年9月之前接种了疫苗,没有参与者在之后接种疫苗。除了在开始和结束时有过短暂的接种,当时只有 28 名参与者未接种疫苗,焦虑症状轨迹在很大程度上是重叠的。到 2022 年 8 月,从未接种过疫苗的参与者焦虑症状较重,但并无其他差异,接种疫苗似乎并没有对焦虑症状轨迹产生有意义的改变:结论:在COVID-19大流行期间,接种疫苗似乎不会影响易感 SSc 患者焦虑症状的变化。这可能是由于患者在未接种疫苗时限制了自己的行为,而在接种疫苗后则恢复了更正常的社交活动,从而保持了焦虑症状的稳定水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of COVID-19 vaccination and anxiety symptoms: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort longitudinal study

Objective

Symptoms of anxiety increased early in the COVID-19 pandemic among people with systemic sclerosis (SSc) then returned to pre-pandemic levels, but this was an aggregate finding and did not evaluate whether vaccination may have contributed to reduced anxiety symptom levels. We investigated whether being vaccinated for COVID-19 was associated with reduced anxiety symptoms among people with SSc.

Methods

The longitudinal Scleroderma Patient-centered Intervention Network (SPIN) COVID-19 Cohort was launched in April 2020 and included participants from the ongoing SPIN Cohort and external enrollees. Participants completed measures bi-weekly through July 2020, then every 4 weeks afterwards through August 2022 (32 assessments). We used linear mixed models to evaluate longitudinal trends of PROMIS Anxiety 4a v1.0 anxiety domain scores and their association with vaccination.

Results

Among 517 participants included in analyses, 489 (95%) were vaccinated by September 2021, and no participants were vaccinated subsequently. Except for briefly at the beginning, when few had received a vaccine, and end, when only 28 participants remained unvaccinated, anxiety symptom trajectories were largely overlapping. Participants who were never vaccinated had higher anxiety symptoms by August 2022, but there were no other differences, and receiving a vaccination did not appear to change anxiety symptom trajectories meaningfully.

Conclusion

Vaccination did not appear to influence changes in anxiety symptoms among vulnerable people with SSc during the COVID-19 pandemic. This may be due to people restricting their behavior when they were unvaccinated and returning to more normal social engagement once vaccinated to maintain a steady level of anxiety symptoms.

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来源期刊
Journal of Psychosomatic Research
Journal of Psychosomatic Research 医学-精神病学
CiteScore
7.40
自引率
6.40%
发文量
314
审稿时长
6.2 weeks
期刊介绍: The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.
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