韩国儿童接触氟化物与疾病负担和神经发育结果的关系。

IF 6.1 2区 医学 Q1 PEDIATRICS
World Journal of Pediatrics Pub Date : 2024-10-01 Epub Date: 2024-06-27 DOI:10.1007/s12519-024-00820-3
Won Seok Lee, Ju Hee Kim, Boeun Han, Gi Chun Lee, Hye Ri Jung, Ye Jin Shin, Eun Kyo Ha, Eun Lee, Soonchul Lee, Man Yong Han
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引用次数: 0

摘要

背景:社区饮水加氟是一项有效的预防龋齿的公共卫生策略。潜在的健康问题令人担忧。本研究探讨了自来水含氟量与儿科疾病负担以及 6 岁儿童神经发育结果之间的关系:这项以全国人口为基础的队列研究纳入了 2006 年至 2012 年间在韩国实施和未实施自来水加氟项目的城市出生的儿童,目标是使处理后的自来水中的氟浓度达到 0.8 ± 0.2 毫克/升。研究使用了国民健康保险服务的数据,时间跨度从出生到2018年。我们研究了接触含氟自来水与16种儿童疾病发病率之间的关系,这些疾病之前已被确认可能与氟接触有关。此外,我们还评估了各个领域的神经发育结果,包括粗大运动、精细运动、认知、语言、社交技能和自助功能。这些评估是利用一项针对六岁儿童的全国性综合健康筛查项目的数据进行的:未接触氟化物组包括22881名儿童,而接触氟化物组包括29991名儿童(52%为男性)。与未接触氟化物组的儿童相比,接触氟化物组的儿童患龋齿和骨折的风险降低[危险比(95% 置信区间,CI)分别为 0.76(0.63-0.93)和 0.89(0.82-0.93)],患肝功能衰竭的风险增加[1.85,(1.14-2.98)]。此外,神经发育异常筛查结果的风险比增加了 9%,但在统计学上并不确定(95% CI,0.95-1.26):含氟自来水与儿童肝功能衰竭风险增加有关,但与骨折风险降低有关。含氟自来水与6岁时神经发育筛查结果之间的关系仍不明确,因此有必要开展进一步研究,以澄清这种关系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association of fluoride exposure with disease burden and neurodevelopment outcomes in children in South Korea.

Association of fluoride exposure with disease burden and neurodevelopment outcomes in children in South Korea.

Background: Community water fluoridation is an effective public health strategy for preventing dental caries, yet. Concerns exist about potential health problems. This study explores associations between tap water fluoride levels and pediatric disease burden, as well as neurodevelopmental outcomes at 6 years of age.

Methods: This nationwide population-based cohort study included children born in Korean cities with and without tap water fluoridation projects, between 2006 and 2012, aiming for a fluoride concentration of 0.8 ± 0.2 mg/L in treated tap water. Data from the National Health Insurance Service were used, spanning from birth to 2018. The relationship between exposure to fluoridated tap water and incidence of 16 childhood diseases that were previously identified as potentially linked to fluoride exposure were examined. Additionally, we evaluated the neurodevelopmental outcomes across various domains, including gross motor, fine motor, cognition, language, social skills, and self-help functions. These assessments were performed using data from a comprehensive national health screening program for children aged six years.

Results: A fluoride-unexposed group included 22,881 children, whereas a fluoride-exposed group comprised 29,991 children (52% males). Children in the fluoride-exposed group had a decreased risk of dental caries and bone fractures [hazard ratio (95% confidence interval, CI), 0.76 (0.63-0.93) and 0.89 (0.82-0.93), respectively] and increased risk of hepatic failures [1.85, (1.14-2.98)] compared to those in the unexposed group. Additionally, the risk ratio of abnormal neurodevelopmental screening outcomes increased by 9%, but this was statistically uncertain (95% CI, 0.95-1.26).

Conclusions: Fluoridated tap water was associated with an increased risk of hepatic failure but a decreased risk of bone fractures in children. The association between fluoridated tap water and neurodevelopmental screening outcomes at 6 years remains unclear, highlighting the need for further studies to clarify this association.

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来源期刊
World Journal of Pediatrics
World Journal of Pediatrics 医学-小儿科
CiteScore
10.50
自引率
1.10%
发文量
592
审稿时长
2.5 months
期刊介绍: The World Journal of Pediatrics, a monthly publication, is dedicated to disseminating peer-reviewed original papers, reviews, and special reports focusing on clinical practice and research in pediatrics. We welcome contributions from pediatricians worldwide on new developments across all areas of pediatrics, including pediatric surgery, preventive healthcare, pharmacology, stomatology, and biomedicine. The journal also covers basic sciences and experimental work, serving as a comprehensive academic platform for the international exchange of medical findings.
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