红外荧光引导手术用于检测头颈癌的肿瘤和转移淋巴结

IF 5.6 Q1 ONCOLOGY
Haley W White, Abdullah Bin Naveed, Benjamin R Campbell, Yu-Jin Lee, Fred M Baik, Michael Topf, Eben L Rosenthal, Marisa E Hom
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引用次数: 0

摘要

在头颈癌(HNC)患者中,手术切除癌组织的总生存率最高。然而,在过去的 30 年中,切除过程中未能获得阴性边缘一直是一个令人担忧的问题。改进肿瘤切除和边缘评估的需求一直是该领域关注的问题。虽然近红外制剂在成像中的应用由来已久,但在过去十年中,用于 HNC 成像的近红外制剂的研究急剧增加。用于原发和转移淋巴结检测的靶向示踪剂尤其引人关注,帕尼单抗-IRDye800 是目前研究中的主要候选药物。本综述旨在概述用于临床检测HNC恶性组织和前哨淋巴结的术中近红外荧光引导手术技术,重点介绍该技术在该领域的当前应用、局限性和未来发展方向。关键词分子成像-癌症、荧光 © RSNA, 2024.
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Infrared Fluorescence-guided Surgery for Tumor and Metastatic Lymph Node Detection in Head and Neck Cancer.

In patients with head and neck cancer (HNC), surgical removal of cancerous tissue presents the best overall survival rate. However, failure to obtain negative margins during resection has remained a steady concern over the past 3 decades. The need for improved tumor removal and margin assessment presents an ongoing concern for the field. While near-infrared agents have long been used in imaging, investigation of these agents for use in HNC imaging has dramatically expanded in the past decade. Targeted tracers for use in primary and metastatic lymph node detection are of particular interest, with panitumumab-IRDye800 as a major candidate in current studies. This review aims to provide an overview of intraoperative near-infrared fluorescence-guided surgery techniques used in the clinical detection of malignant tissue and sentinel lymph nodes in HNC, highlighting current applications, limitations, and future directions for use of this technology within the field. Keywords: Molecular Imaging-Cancer, Fluorescence © RSNA, 2024.

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