乳腺癌中 Wnt 信号分子与外泌体 miRNA 之间的相互作用（综述）。

IF 3.8 3区医学 Q2 ONCOLOGY

Oncology reports Pub Date : 2024-08-01 Epub Date: 2024-06-28 DOI:10.3892/or.2024.8766

Hailong Li, Xia Li, Wei Du

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引用次数: 0

摘要

乳腺癌（BC）是全球妇女最常见的恶性肿瘤。Wnt 信号参与肿瘤发生和癌症进展，并与乳腺癌的特征密切相关。外泌体微RNA（miRNA）表达的变化可调节关键的癌症表型，如细胞增殖、上皮-间质转化、转移潜能、免疫逃避和耐药性。本综述旨在讨论 Wnt 信号转导和外泌体 miRNA 在调控 BC 发生和发展中的重要性。此外，本综述还确定了 Wnt 信号转导与外泌体 miRNA 之间的相互影响，并强调了潜在的诊断生物标志物和治疗靶点。

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Interplay between Wnt signaling molecules and exosomal miRNAs in breast cancer (Review).

Breast cancer (BC) is the most common malignancy in women worldwide. Wnt signaling is involved in tumorigenesis and cancer progression, and is closely associated with the characteristics of BC. Variation in the expression of exosomal microRNAs (miRNAs) modulates key cancer phenotypes, such as cellular proliferation, epithelial‑mesenchymal transition, metastatic potential, immune evasion and treatment resistance. The present review aimed to discuss the importance of Wnt signaling and exosomal miRNAs in regulating the occurrence and development of BC. In addition, the present review determined the crosstalk between Wnt signaling and exosomal miRNAs, and highlighted potential diagnostic biomarkers and therapeutic targets.

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来源期刊

Oncology reports 医学-肿瘤学

CiteScore

8.50

自引率

2.40%

发文量

187

审稿时长

3 months

期刊介绍： Oncology Reports is a monthly, peer-reviewed journal devoted to the publication of high quality original studies and reviews concerning a broad and comprehensive view of fundamental and applied research in oncology, focusing on carcinogenesis, metastasis and epidemiology.