2019 年从日本分离的基因型 2.1 经典猪瘟病毒在猪身上的致病性。

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Maiko Yamashita, Shoko Iwamoto, Mariko Ochiai, Atsushi Yamamoto, Kasumi Sudo, Rie Narushima, Takao Nagasaka, Akito Saito, Mami Oba, Tsutomu Omatsu, Tetsuya Mizutani, Kinya Yamamoto
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引用次数: 0

摘要

2018 年,典型猪瘟(CSF)26 年来首次在日本再次出现。据了解,该病是由中度致病性病毒引起的,而不是过去发生的高致病性病毒。然而,其潜在的病理生理学仍然未知。本研究对无特定病原体(SPF)猪进行了为期 2 周、4 周和 6 周的试验性挑战,并通过临床观察、病毒检测和病理解剖确认了每个时期的疾病状态。我们揭示了病毒挑战后各个时期的病理变化以及病原体和病毒特异性抗体的分布情况。对这些结果进行了综合分析,约 70% 的猪只恢复了健康,尤其是在病毒挑战后 4 周和 6 周。本研究阐明了未接种疫苗的猪感染中度致病性基因型 2.1 病毒后的致病性结果,为今后采取 CSF 对策提供了有用信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Pathogenicity of genotype 2.1 classical swine fever virus isolated from Japan in 2019 in pigs

Pathogenicity of genotype 2.1 classical swine fever virus isolated from Japan in 2019 in pigs

Classical swine fever (CSF) re-emerged in Japan in 2018 for the first time in 26 years. The disease has been known to be caused by a moderately pathogenic virus, rather than the highly pathogenic virus that had occurred in the past. However, the underlying pathophysiology remains unknown. This study conducted an experimental challenge on specific pathogen-free (SPF) pigs in a naïve state for 2, 4, and 6 weeks and confirmed the disease state during each period by clinical observation, virus detection, and pathological necropsy. We revealed the pathological changes and distribution of pathogens and virus-specific antibodies at each period after virus challenge. These results were comprehensively analyzed and approximately 70% of the pigs recovered, especially at 4- and 6-week post-virus challenge. This study provides useful information for future countermeasures against CSF by clarifying the pathogenicity outcomes in unvaccinated pigs with moderately pathogenic genotype 2.1 virus.

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来源期刊
Microbiology and Immunology
Microbiology and Immunology 医学-免疫学
CiteScore
5.20
自引率
3.80%
发文量
78
审稿时长
1 months
期刊介绍: Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.
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