临床前测定大比目鱼油膏在大鼠烧伤模型中的伤口愈合活性。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-12-01 Epub Date: 2024-07-01 DOI:10.1080/10286020.2024.2368835

S T Shukla, Anu Kaushik, Samiullah Allahbaksh Auti, Dinesh Kumar, Supriya Kumar Das

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引用次数: 0

摘要

本研究调查了含有欧米茄-3 脂肪酸、维生素 A 和 D 以及羟脯氨酸的比目鱼油膏对大鼠烧伤伤口愈合的影响。急性皮肤毒性试验证实其无毒性。Wistar 大鼠被分为五组：一组为对照组，一组为使用 1%磺胺嘧啶银（SSD）治疗的阳性对照组，三组分别使用 3%、9% 和 27% 的大比目鱼油膏配方（HBOF）治疗。与对照组相比，磺胺嘧啶银组和比目鱼油膏组的愈合效果显著。组织病理学分析表明，HBOF 组的胶原蛋白生成增加，这表明大比目鱼油膏具有局部治疗烧伤创面的潜力。

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Preclinical determination of wound-healing activity of halibut oil cream in rat model of burn wound.

This study investigated the effects of halibut oil cream, containing omega-3 fatty acids, vitamins A and D, and hydroxyproline, on burn wound healing in rats. Acute dermal toxicity tests confirmed its nontoxicity. Wistar rats were divided into five groups: a control, a positive control treated with silver sulfadiazine 1% (SSD), and three groups treated with 3%, 9%, and 27% halibut oil cream Formulation (HBOF). The SSD and HBOF groups showed significant healing improvements compared to the control. Histopathological analysis indicated increased collagen production in the HBOF groups, suggesting halibut oil cream's potential as a topical treatment for burn wounds.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.