利用水力增溶技术提高橙皮甙和柚皮甙的水溶性：特征描述和体外评估。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-06-26 DOI:10.1080/10286020.2024.2358831

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引用次数: 0

摘要

由于药代动力学问题，尤其是水溶性差，橙皮甙和柚皮甙这两种重要黄酮类化合物的治疗潜力仍未得到充分利用。添加了水杨酸钠、烟酰胺、苯甲酸和尿素等不同药剂的水合固体分散体可以改变溶解性差的药物的溶解度曲线。目前的研究调查了不同的亲水剂在改善两种天然生物活性物质溶解度方面的潜力。在所有测试的水促剂中，药物与水杨酸钠重量比为 1:3 的水促剂固体分散体显示出最大的溶解度和溶解度。这种新颖而经济的方法可用于其他溶解性较差的药物。

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Enhancement of aqueous solubility of hesperidin and naringenin utilizing hydrotropic solubilization technique: characterization and in vitro evaluation

The therapeutic potential of two important flavonoids, i.e. hesperidin and naringenin, remains unutilized due to pharmacokinetics issues, especially poor aqueous solubility. Hydrotropic solid dispersions with different agents like sodium salicylate, niacinamide, benzoic acid, and urea etc. can change the solubility profile of poorly soluble drugs. The current study investigated the potential of different hydrotropic agents in improving the solubility of both natural bioactives. The hydrotropic solid dispersion in 1:3 w/w drug: sodium salicylate ratio showed maximum solubility and dissolution amongst all the tested hydrotropes. This novel and economical approach could be explored for other poorly soluble pharmaceuticals.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.