肉样肥胖可预测胃癌新辅助化疗和手术后的短期和长期预后。

IF 1.9 4区 医学 Q3 ONCOLOGY
Chunning Duan, Mingru Wu, Xia Wen, Lvping Zhuang, Jianwei Sun
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引用次数: 0

摘要

背景:肉样肥胖(SO)会影响各种恶性肿瘤的治疗效果。然而,其对局部晚期胃癌(LAGC)新辅助化疗(NAC)患者的临床意义仍不明确。本研究调查了新辅助化疗前后SO对术后发病率和生存率的影响:研究回顾了 2010 年 1 月至 2019 年 10 月间接受 NAC 后进行根治性胃切除术的 207 例 LAGC 患者的数据。使用计算机断层扫描测量了NAC术前和术后的骨骼肌质量和内脏脂肪面积,以确定肌肉疏松症和肥胖症,并将两者同时存在定义为SO.Results:患者中分别有 52 人(25.1%)和 38 人(18.4%)在接受 NAC 之前和之后出现 SO。NAC术前(34.6%)和术后(47.4%)SO与最高的术后发病率相关;然而,只有NAC术后SO是术后发病率的独立风险因素[危险比(HR)= 9.550,95%置信区间(CI)= 2.818-32.369;P 结论:NAC术前SO是术后发病率的独立风险因素:在接受 NAC 手术的 LAGC 患者中,NAC 术前 SO 是一个独立的预后因素;NAC 术后 SO 可独立预测术后发病率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sarcopenic obesity predicts short- and long-term outcomes after neoadjuvant chemotherapy and surgery for gastric cancer.

Background: Sarcopenic obesity (SO) affects outcomes in various malignancies. However, its clinical significance in patients undergoing neoadjuvant chemotherapy (NAC) for locally advanced gastric cancer (LAGC) remains unclear. This study investigated the impact of pre- and post-NAC SO on postoperative morbidity and survival.

Methods: Data from 207 patients with LAGC, who underwent NAC followed by radical gastrectomy between January 2010 and October 2019, were reviewed. Skeletal muscle mass and visceral fat area were measured pre- and post-NAC using computed tomography to define sarcopenia and obesity, the coexistence of which was defined as SO.

Results: Among the patients, 52 (25.1%) and 38 (18.4%) developed SO before and after NAC, respectively. Both pre- (34.6%) and post- (47.4%) NAC SO were associated with the highest postoperative morbidity rates; however, only post-NAC SO was an independent risk factor for postoperative morbidity [hazard ratio (HR) = 9.550, 95% confidence interval (CI) = 2.818-32.369; P < .001]. Pre-NAC SO was independently associated with poorer 3-year overall [46.2% vs. 61.3%; HR = 1.258 (95% CI = 1.023-1.547); P = .049] and recurrence-free [39.3% vs. 55.4%; HR 1.285 (95% CI 1.045-1.579); P = .017] survival.

Conclusions: Pre-NAC SO was an independent prognostic factor in patients with LAGC undergoing NAC; post-NAC SO independently predicted postoperative morbidity.

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来源期刊
CiteScore
3.70
自引率
8.30%
发文量
177
审稿时长
3-8 weeks
期刊介绍: Japanese Journal of Clinical Oncology is a multidisciplinary journal for clinical oncologists which strives to publish high quality manuscripts addressing medical oncology, clinical trials, radiology, surgery, basic research, and palliative care. The journal aims to contribute to the world"s scientific community with special attention to the area of clinical oncology and the Asian region. JJCO publishes various articles types including: ・Original Articles ・Case Reports ・Clinical Trial Notes ・Cancer Genetics Reports ・Epidemiology Notes ・Technical Notes ・Short Communications ・Letters to the Editors ・Solicited Reviews
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