体重指数对促性腺激素释放激素拮抗剂周期触发日孕酮水平的影响。

IF 2 4区 医学 Q3 ENDOCRINOLOGY & METABOLISM
Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-06-30 DOI:10.1080/09513590.2024.2364892
Yating Sun, Aizhen Zhu
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引用次数: 0

摘要

目的调查体重指数(BMI)对促性腺激素释放激素拮抗剂(GnRH-ant)周期触发日孕酮(P)水平的影响:本研究为回顾性队列研究。选取2017年10月至2022年4月在我院生殖中心接受GnRH-ant方案治疗控制性卵巢过度刺激(COH)的412例体外受精(IVF)/卵胞浆内单精子注射(ICSI)患者作为研究对象。根据BMI水平将患者分为三组:正常体重组(n = 230):18.5 kg/m2≤BMI < 24 kg/m2;超重组(n = 122):24 kg/m2≤BMI < 28 kg/m2;肥胖组(n = 60):体重指数≥28 kg/m2。在多变量逻辑回归模型中加入了触发日P 2水平的变量)和可能影响触发日P水平的变量(不孕不育因素、基础LH、总FSH、HMG天数和总HMG),以分析BMI对GnRH-ant方案触发日P水平的影响:结果:调整混杂因素后,与正常体重患者相比,超重和肥胖患者触发日血清 P 升高的风险显著降低(OR = 0.434 和 0.199,P 结论:超重和肥胖患者触发日血清 P 升高的风险显著降低(OR = 0.434 和 0.199,P 结论):GnRH-ant周期触发日P升高的风险随着体重指数的增加而降低,体重指数可作为GnRH-ant周期触发日P水平的预测因子之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of body mass index on progesterone level on trigger day in gonadotropin-releasing hormone antagonist cycles.

Objective: To investigate the effect of body mass index (BMI) on progesterone (P) level on trigger day in gonadotropin-releasing hormone antagonist (GnRH-ant) cycles.

Methods: This study was a retrospective cohort study. From October 2017 to April 2022, 412 in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) patients who were treated with GnRH-ant protocol for controlled ovarian hyperstimulation (COH) in the reproductive center of our hospital were selected as the research objects. Patients were divided into three groups according to BMI level: normal weight group (n = 230):18.5 kg/m2≤BMI < 24 kg/m2; overweight group (n = 122): 24 kg/m2≤BMI < 28 kg/m2; Obesity group (n = 60): BMI ≥ 28 kg/m2. Variables with p < .10 in univariate analysis (BMI, basal FSH, basal P, FSH days, Gn starting dose and E2 level on trigger day) and variables that may affect P level on trigger day (infertility factors, basal LH, total FSH, HMG days and total HMG) were included in the multivariate logistic regression model to analyze the effect of BMI on P level on trigger day of GnRH-ant protocol.

Results: After adjustment for confounding factors, compared with that in normal weight patients, the risk of serum P elevation on trigger day was significantly lower in overweight and obese patients (OR = 0.434 and 0.199, respectively, p < .05).

Conclusion: The risk of P elevation on trigger day in GnRH-ant cycles decreased with the increase of BMI, and BMI could be used as one of the predictors of P level on trigger day in GnRH-ant cycles.

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来源期刊
Gynecological Endocrinology
Gynecological Endocrinology 医学-妇产科学
CiteScore
4.40
自引率
5.00%
发文量
137
审稿时长
3-6 weeks
期刊介绍: Gynecological Endocrinology , the official journal of the International Society of Gynecological Endocrinology, covers all the experimental, clinical and therapeutic aspects of this ever more important discipline. It includes, amongst others, papers relating to the control and function of the different endocrine glands in females, the effects of reproductive events on the endocrine system, and the consequences of endocrine disorders on reproduction
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