阴茎微生物组:解码其对 HIV 风险的影响。

Current opinion in HIV and AIDS Pub Date : 2024-09-01 Epub Date: 2024-06-17 DOI:10.1097/COH.0000000000000865
Sydney G Nelson, Cindy M Liu
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引用次数: 0

摘要

综述的目的:阴茎微生物组与局部炎症和性传播感染(包括 HIV)风险增加有关。本综述探讨了这一艾滋病研究新兴领域的最新研究:男性泌尿生殖道支持多个不同的龛位,其相关微生物组受非生物(如氧气、湿度)和生物(如宿主免疫)环境因素以及宿主行为(尤其是性行为)的影响。此外,包皮环切术是儿童和成人男性生殖器微生物组的重要驱动因素。摘要:男性生殖器微生物组受当地微环境和宿主行为(包括性活动)的影响。提高我们对男性生殖器微生物组、局部炎症和艾滋病易感性之间的联系以及促炎性生殖器细菌如何在性伴侣之间传播的认识,可为预防艾滋病传播的新策略提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Penile microbiome: decoding its impact on HIV risk.

Purpose of review: The penile microbiome has been linked to local inflammation and increased risk for sexually transmitted infections, including HIV. This review explores recent studies of this emerging area of HIV research.

Recent findings: The male urogenital tract supports multiple distinct niches, where their associated microbiome are shaped by abiotic (e.g., oxygen, moisture) and biotic (e.g., host immunity) environmental factors and host behaviors, particularly sexual activity. In addition, male circumcision is a significant drivers of male genital microbiome in both children and adults. Recent sexual partner studies provide new insight into the exchange of genital bacteria and concurrent local immune changes that may impact HIV risk.

Summary: The male genital microbiome is shaped by the local microenvironment and host behaviors including sexual activity. Improving our understanding of the connection between the male genital microbiome, local inflammation, and HIV susceptibility, as well as how pro-inflammatory genital bacteria are transmitted between sexual partners may inform new strategies to prevent HIV transmission.

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