生酮饮食对癌症相关变量的影响:随机对照试验的系统回顾和荟萃分析。

IF 2.7 4区 医学 Q3 NUTRITION & DIETETICS
Nutrition Bulletin Pub Date : 2024-09-01 Epub Date: 2024-06-24 DOI:10.1111/nbu.12693
Belinda Salido-Bueno, Esther Gil-Hernandez, Lola Rueda-Ruzafa, Pablo Gomez-Chica, Pablo Roman, Diana Cardona
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引用次数: 0

摘要

癌症是受遗传、环境和生活方式选择影响的全球性健康问题。最近的研究表明,生酮饮食(KD)可以缓解癌症症状并缩小肿瘤。我们假设生酮饮食可以改善癌症相关变量。因此,本研究旨在进行系统回顾和荟萃分析,以评估生酮饮食对癌症患者的疗效。我们利用 PubMed (MEDLINE)、Web of Science、CINAHL 和 Open Grey 等数据库进行了系统综述和荟萃分析。分析仅限于年龄在 18 岁及以上的成年参与者参加的随机对照试验。在进行 KD 后,对血糖、胆固醇、胰岛素样生长因子 1、体重和生活质量水平进行了评估。在初步搜索中确定了 596 篇文章后,有 8 项持续 4 到 16 周的研究被纳入系统综述,7 项被纳入荟萃分析。KD 可降低癌症患者的血糖水平,但在胆固醇、胰岛素样生长因子 1、体重或生活质量方面没有明显改善。根据本次系统综述和荟萃分析的结果,目前还没有足够的证据证明 KD 与癌症相关指标之间存在明确的联系。虽然一些研究表明,在某些结果和肿瘤缩小方面存在潜在的益处,但要全面了解这种饮食的效果,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of ketogenic diets on cancer-related variables: A systematic review and meta-analysis of randomised controlled trials.

Cancer is a global health concern influenced by genetics, environment and lifestyle choices. Recent research shows that a ketogenic diet (KD) might ease cancer symptoms and reduce tumour size. We hypothesised that the KD could result in improvements in cancer-related variables. Therefore, this study aims to perform a systematic review and meta-analysis to assess the KD's efficacy for patients with cancer. The databases PubMed (MEDLINE), Web of Science, CINAHL and Open Grey were utilised for conducting a systematic review and meta-analysis. The analysis was limited to randomised controlled trials with adult participants aged 18 years and above. Levels of glucose, cholesterol, insulin-like growth factor 1, weight and quality of life were evaluated following the KD. After identifying 596 articles in the initial search, eight studies, lasting between 4 and 16 weeks, were included in the systematic review and seven in the meta-analysis. The KD led to decreased glucose levels in patients with cancer but did not show significant improvements in cholesterol, insulin-like growth factor 1, weight or quality of life. Based on the results of this systematic review and meta-analysis, there is insufficient evidence to establish a definitive link between the KD and cancer-related parameters. While some studies suggest potential benefits in terms of some outcomes and tumour size reduction, further research is required to fully comprehend the effects of this diet.

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来源期刊
Nutrition Bulletin
Nutrition Bulletin NUTRITION & DIETETICS-
CiteScore
4.50
自引率
12.10%
发文量
58
期刊介绍: The Nutrition Bulletin provides accessible reviews at the cutting edge of research. Read by researchers and nutritionists working in universities and research institutes; public health nutritionists, dieticians and other health professionals; nutritionists, technologists and others in the food industry; those engaged in higher education including students; and journalists with an interest in nutrition.
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