Anne Søndergaard, Maja Gregersen, Martin Wilms, Julie Marie Brandt, Carsten Hjorthøj, Jessica Ohland, Sinnika Birkehøj Rohd, Nicoline Hemager, Anna Krogh Andreassen, Christina Bruun Knudsen, Lotte Veddum, Mette Falkenberg Krantz, Aja Greve, Vibeke Bliksted, Ole Mors, Kasper Lykkegaard, Peter Krustrup, Anne E Thorup, Merete Nordentoft
{"title":"11 岁精神分裂症或躁郁症家族高风险儿童的炎症指标、躯体不适、药物使用和医疗保健情况与人群对照组的比较。丹麦高风险与复原力研究》--第 11 期。","authors":"Anne Søndergaard, Maja Gregersen, Martin Wilms, Julie Marie Brandt, Carsten Hjorthøj, Jessica Ohland, Sinnika Birkehøj Rohd, Nicoline Hemager, Anna Krogh Andreassen, Christina Bruun Knudsen, Lotte Veddum, Mette Falkenberg Krantz, Aja Greve, Vibeke Bliksted, Ole Mors, Kasper Lykkegaard, Peter Krustrup, Anne E Thorup, Merete Nordentoft","doi":"10.1080/08039488.2024.2369145","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Patients with schizophrenia or bipolar disorder are at increased risk of somatic illnesses and have more somatic complaints compared with the general population. Schizophrenia and bipolar disorder are highly heritable. Already during childhood, children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BD) are at increased risk of psychiatric disorders and cognitive and social impairments. Knowledge about physical conditions is sparse.</p><p><strong>Materials and methods: </strong>Through blood tests (<i>n</i> = 293), interviews, and questionnaires, we assessed inflammatory markers, somatic complaints, medication - and health care use in 11-year-old children at FHR-SZ, FHR-BD, and population-based controls (PBC).</p><p><strong>Results: </strong>Children at FHR-SZ had higher concentrations of leucocytes (mean 6.41, <i>SD</i> 0.73) compared with PBC (mean 5.78, <i>SD</i> 0.27, <i>p</i> = 0.005) and of neutrophilocytes (FHR-SZ: mean 3.11, <i>SD</i> 1.32, PBC: mean 2.70, <i>SD</i> 0.96, <i>p</i> = 0.024). Compared with PBC (26.6%), more children at FHR-SZ (40.5%, <i>p</i> = 0.007) reported somatic complaints. So did caregivers and teachers to children at FHR-BD. Somatic complaints, higher concentrations of leucocytes, and neutrophilocytes were associated with lower levels of physical activity. Children at FHR-BD with psychiatric disorders reported more somatic complaints compared with those without.</p><p><strong>Conclusion: </strong>Children at FHR-SZ had higher concentrations of leucocytes and neutrophilocytes than PBC. Children at FHR-SZ or FHR-BP displayed more somatic complaints than controls. Our study highlights rarely explored disadvantage of being born to parents with schizophrenia or bipolar disorder. To enhance understanding of how physical conditions in childhood may interplay with later transition to mental disorders in children at FHR-SZ and FHR-BD, further research is needed.</p>","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"507-517"},"PeriodicalIF":1.5000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inflammatory markers, somatic complaints, use of medication and health care in 11-year-old children at familial high risk of schizophrenia or bipolar disorder compared with population-based controls. The Danish High Risk and Resilience Study - via 11.\",\"authors\":\"Anne Søndergaard, Maja Gregersen, Martin Wilms, Julie Marie Brandt, Carsten Hjorthøj, Jessica Ohland, Sinnika Birkehøj Rohd, Nicoline Hemager, Anna Krogh Andreassen, Christina Bruun Knudsen, Lotte Veddum, Mette Falkenberg Krantz, Aja Greve, Vibeke Bliksted, Ole Mors, Kasper Lykkegaard, Peter Krustrup, Anne E Thorup, Merete Nordentoft\",\"doi\":\"10.1080/08039488.2024.2369145\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Patients with schizophrenia or bipolar disorder are at increased risk of somatic illnesses and have more somatic complaints compared with the general population. Schizophrenia and bipolar disorder are highly heritable. Already during childhood, children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BD) are at increased risk of psychiatric disorders and cognitive and social impairments. Knowledge about physical conditions is sparse.</p><p><strong>Materials and methods: </strong>Through blood tests (<i>n</i> = 293), interviews, and questionnaires, we assessed inflammatory markers, somatic complaints, medication - and health care use in 11-year-old children at FHR-SZ, FHR-BD, and population-based controls (PBC).</p><p><strong>Results: </strong>Children at FHR-SZ had higher concentrations of leucocytes (mean 6.41, <i>SD</i> 0.73) compared with PBC (mean 5.78, <i>SD</i> 0.27, <i>p</i> = 0.005) and of neutrophilocytes (FHR-SZ: mean 3.11, <i>SD</i> 1.32, PBC: mean 2.70, <i>SD</i> 0.96, <i>p</i> = 0.024). Compared with PBC (26.6%), more children at FHR-SZ (40.5%, <i>p</i> = 0.007) reported somatic complaints. So did caregivers and teachers to children at FHR-BD. Somatic complaints, higher concentrations of leucocytes, and neutrophilocytes were associated with lower levels of physical activity. Children at FHR-BD with psychiatric disorders reported more somatic complaints compared with those without.</p><p><strong>Conclusion: </strong>Children at FHR-SZ had higher concentrations of leucocytes and neutrophilocytes than PBC. Children at FHR-SZ or FHR-BP displayed more somatic complaints than controls. Our study highlights rarely explored disadvantage of being born to parents with schizophrenia or bipolar disorder. To enhance understanding of how physical conditions in childhood may interplay with later transition to mental disorders in children at FHR-SZ and FHR-BD, further research is needed.</p>\",\"PeriodicalId\":19201,\"journal\":{\"name\":\"Nordic Journal of Psychiatry\",\"volume\":\" \",\"pages\":\"507-517\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nordic Journal of Psychiatry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/08039488.2024.2369145\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nordic Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08039488.2024.2369145","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Inflammatory markers, somatic complaints, use of medication and health care in 11-year-old children at familial high risk of schizophrenia or bipolar disorder compared with population-based controls. The Danish High Risk and Resilience Study - via 11.
Purpose: Patients with schizophrenia or bipolar disorder are at increased risk of somatic illnesses and have more somatic complaints compared with the general population. Schizophrenia and bipolar disorder are highly heritable. Already during childhood, children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BD) are at increased risk of psychiatric disorders and cognitive and social impairments. Knowledge about physical conditions is sparse.
Materials and methods: Through blood tests (n = 293), interviews, and questionnaires, we assessed inflammatory markers, somatic complaints, medication - and health care use in 11-year-old children at FHR-SZ, FHR-BD, and population-based controls (PBC).
Results: Children at FHR-SZ had higher concentrations of leucocytes (mean 6.41, SD 0.73) compared with PBC (mean 5.78, SD 0.27, p = 0.005) and of neutrophilocytes (FHR-SZ: mean 3.11, SD 1.32, PBC: mean 2.70, SD 0.96, p = 0.024). Compared with PBC (26.6%), more children at FHR-SZ (40.5%, p = 0.007) reported somatic complaints. So did caregivers and teachers to children at FHR-BD. Somatic complaints, higher concentrations of leucocytes, and neutrophilocytes were associated with lower levels of physical activity. Children at FHR-BD with psychiatric disorders reported more somatic complaints compared with those without.
Conclusion: Children at FHR-SZ had higher concentrations of leucocytes and neutrophilocytes than PBC. Children at FHR-SZ or FHR-BP displayed more somatic complaints than controls. Our study highlights rarely explored disadvantage of being born to parents with schizophrenia or bipolar disorder. To enhance understanding of how physical conditions in childhood may interplay with later transition to mental disorders in children at FHR-SZ and FHR-BD, further research is needed.
期刊介绍：
Nordic Journal of Psychiatry publishes international research on all areas of psychiatry.
Nordic Journal of Psychiatry is the official journal for the eight psychiatry associations in the Nordic and Baltic countries. The journal aims to provide a leading international forum for high quality research on all themes of psychiatry including:
Child psychiatry
Adult psychiatry
Psychotherapy
Pharmacotherapy
Social psychiatry
Psychosomatic medicine
Nordic Journal of Psychiatry accepts original research articles, review articles, brief reports, editorials and letters to the editor.
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