丹参酮 IIA 和四甲基吡嗪纳米乳剂对阿尔茨海默病大鼠模型认知障碍和神经元损伤的治疗作用

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmacy and Pharmacology Pub Date : 2024-09-03 DOI:10.1093/jpp/rgae069

Liang Fang, Hongyan Cheng, Weidong Chen, Can Peng, Yuanxu Liu, Caiyun Zhang

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引用次数: 0

摘要

研究目的本研究旨在探讨丹参酮 IIA 和四甲基吡嗪 O/W 复合纳米乳剂对阿尔茨海默病（AD）大鼠的治疗作用及相关机制：方法：通过行为测试、H&E、Nissl和免疫组化染色评估TSN/TMP O/W纳米乳剂对AD大鼠的治疗效果。主要研究结果：结果表明，TSN/TMP O/W NEs能下调Bax和Caspase-3蛋白的表达，降低MDA水平，增加SOD和GSH-Px的表达，缓解AD大鼠的认知障碍：结论：TSN/TMP O/W NEs能抑制MAPK/ERK/CREB信号通路，有效缓解AD大鼠的认知障碍、氧化应激损伤和神经细胞凋亡。

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Therapeutic effects of Tanshinone IIA and Tetramethylpyrazine nanoemulsions on cognitive impairment and neuronal damage in Alzheimer's disease rat models.

Objectives: The aim of this study was to investigate the therapeutic effects and related mechanisms of Tanshinone IIA and Tetramethylpyrazine O/W composite nanoemulsions on Alzheimer's disease (AD) rats.

Methods: The therapeutic effect of TSN/TMP O/W NEs on AD rats was evaluated by behavioral tests, H&E, Nissl, and Immunohistochemistry staining. ELISA and Western blot were used to analyze the mechanism.

Key findings: The results showed that TSN/TMP O/W NEs could down-regulate the expression of Bax and Caspase-3 proteins, decrease the level of MDA, increase the expression of SOD and GSH-Px, and alleviate cognitive impairment in AD rats.

Conclusions: TSN/TMP O/W NEs can inhibit MAPK/ERK/CREB signaling pathway and effectively alleviate cognitive impairment, oxidative stress injury, and neuronal apoptosis in AD rats.

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来源期刊

Journal of Pharmacy and Pharmacology 医学-药学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.