{"title":"膳食茴香醚:关于其对代谢综合征的保护作用的系统综述。","authors":"Fatemeh Dehbashizadeh Torghabeh, Behjat Javadi, Amirhossein Sahebkar","doi":"10.1007/s40200-023-01322-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) is a cluster of physiological, biochemical, clinical, and metabolic conditions that aggravate the risk of severe diseases such as cardiovascular disease, type 2 diabetes mellitus, and fatty liver. Several dietary molecules have been considered preventive compounds for MetS. Anethole, a natural phenylpropanoid, has been found to protect against MetS and its associated components.</p><p><strong>Aim: </strong>This systematic review aims to provide an overview of the preclinical evidence supporting the protective effects of dietary anethole against MetS and the associated diseases.</p><p><strong>Methods: </strong>A literature search was performed using Web of Sciences, PubMed, Scopus, and Google Scholar to identify studies reporting the protective effects of dietary anethole against MetS, without any time restrictions. Review articles, letters to editors, editorials, unpublished results, and non-English papers were excluded from the study.</p><p><strong>Results: </strong>The results showed that anethole has the potential to effectively protect against the key features of MetS via various mechanisms, including antioxidant and anti-inflammatory effects, stimulating insulin secretion from β-cells, mediating oxidative stress, modulation of the mTOR/PPARγ axis, arterial remodeling, and improvement of vascular relaxation.</p><p><strong>Conclusion: </strong>Anethole modulates several molecular pathways that are implicated in the pathogenesis of MetS. Future in vitro and animal investigations should be conducted to explore other anti-MetS signaling pathways of anethole. Additionally, well-designed clinical studies are warranted to determine the optimal human dose, bioavailability, and pharmacokinetic characteristics of this dietary compound.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196516/pdf/","citationCount":"0","resultStr":"{\"title\":\"Dietary anethole: a systematic review of its protective effects against metabolic syndrome.\",\"authors\":\"Fatemeh Dehbashizadeh Torghabeh, Behjat Javadi, Amirhossein Sahebkar\",\"doi\":\"10.1007/s40200-023-01322-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Metabolic syndrome (MetS) is a cluster of physiological, biochemical, clinical, and metabolic conditions that aggravate the risk of severe diseases such as cardiovascular disease, type 2 diabetes mellitus, and fatty liver. 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Review articles, letters to editors, editorials, unpublished results, and non-English papers were excluded from the study.</p><p><strong>Results: </strong>The results showed that anethole has the potential to effectively protect against the key features of MetS via various mechanisms, including antioxidant and anti-inflammatory effects, stimulating insulin secretion from β-cells, mediating oxidative stress, modulation of the mTOR/PPARγ axis, arterial remodeling, and improvement of vascular relaxation.</p><p><strong>Conclusion: </strong>Anethole modulates several molecular pathways that are implicated in the pathogenesis of MetS. Future in vitro and animal investigations should be conducted to explore other anti-MetS signaling pathways of anethole. 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引用次数: 0
摘要
背景:代谢综合征(MetS)是一组生理、生化、临床和代谢症状,会增加罹患心血管疾病、2 型糖尿病和脂肪肝等严重疾病的风险。有几种膳食分子被认为是 MetS 的预防化合物。目的:本系统综述旨在概述支持膳食中的茴香硫醚对 MetS 及其相关疾病具有保护作用的临床前证据:方法:使用 Web of Sciences、PubMed、Scopus 和 Google Scholar 进行文献检索,以确定报告茴香硫醚对 MetS 有保护作用的研究,不受时间限制。研究排除了评论文章、致编辑的信、社论、未发表的结果和非英文论文:结果:研究结果表明,茴香硫醚可通过多种机制有效预防 MetS 的主要特征,包括抗氧化和抗炎作用、刺激 β 细胞分泌胰岛素、介导氧化应激、调节 mTOR/PPARγ 轴、动脉重塑和改善血管松弛:结论:茴香醚能调节与 MetS 发病机制有关的几种分子通路。未来应开展体外和动物研究,探索茴香醚的其他抗 MetS 信号通路。此外,还需要进行精心设计的临床研究,以确定这种膳食化合物的最佳人体剂量、生物利用率和药代动力学特征。
Dietary anethole: a systematic review of its protective effects against metabolic syndrome.
Background: Metabolic syndrome (MetS) is a cluster of physiological, biochemical, clinical, and metabolic conditions that aggravate the risk of severe diseases such as cardiovascular disease, type 2 diabetes mellitus, and fatty liver. Several dietary molecules have been considered preventive compounds for MetS. Anethole, a natural phenylpropanoid, has been found to protect against MetS and its associated components.
Aim: This systematic review aims to provide an overview of the preclinical evidence supporting the protective effects of dietary anethole against MetS and the associated diseases.
Methods: A literature search was performed using Web of Sciences, PubMed, Scopus, and Google Scholar to identify studies reporting the protective effects of dietary anethole against MetS, without any time restrictions. Review articles, letters to editors, editorials, unpublished results, and non-English papers were excluded from the study.
Results: The results showed that anethole has the potential to effectively protect against the key features of MetS via various mechanisms, including antioxidant and anti-inflammatory effects, stimulating insulin secretion from β-cells, mediating oxidative stress, modulation of the mTOR/PPARγ axis, arterial remodeling, and improvement of vascular relaxation.
Conclusion: Anethole modulates several molecular pathways that are implicated in the pathogenesis of MetS. Future in vitro and animal investigations should be conducted to explore other anti-MetS signaling pathways of anethole. Additionally, well-designed clinical studies are warranted to determine the optimal human dose, bioavailability, and pharmacokinetic characteristics of this dietary compound.
期刊介绍:
Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.