开发含有生物硅酸盐的口腔可分散膜,并确定其对龋齿和腐蚀性牙釉质再矿化的影响。

IF 3.2 4区 医学 Q2 ENGINEERING, BIOMEDICAL
Ayodele Alves Amorim, Eduardo José Soares, Fernanda de Carvalho Panzeri Pires-de-Souza
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引用次数: 0

摘要

研究目的本体外研究的目的是评估将生物硅酸盐颗粒(30 毫克和 50 毫克)加入实验性口腔可分散薄膜的效率及其在致龋和侵蚀挑战下对牛牙釉质再矿化过程的功效:九十九颗完整的门牙,无裂纹或骨折,在水冷条件下使用低速金刚石圆盘进行前庭切片,获得 198 个样本(6 × 6 × 2 毫米)。用 600、1200 和 2000 粗细度的砂纸磨平珐琅质表面后,根据样本所经历的挑战将其分为两组:致龋组(0.1 M 乳酸,pH 值为 5.0)或腐蚀组(0.05 M 柠檬酸溶液,pH 值为 2.3)。根据致龋性(3、7 和 14 天)或侵蚀性(3、7 和 10 天)挑战的持续时间,将每次挑战的样本进一步分为 11 组(n = 9),以及阳性对照组(未经挑战处理并用不同浓度的生物硅酸盐处理的片段)和阴性对照组(用人工唾液处理的片段,处理时间与致龋性和侵蚀性挑战确定的时间相同)。使用含有生物硅酸盐(30 毫克和 50 毫克)的口腔分散膜进行处理,每天 2 分钟,持续 15 天:结果:在经过 14 天的致龋挑战后,使用生物硅酸盐处理的样本具有最高的再矿化潜能,无论测试的浓度是多少。对于受到侵蚀性挑战的样品,侵蚀时间并不影响 Biosilicate 的再矿化潜力:结论:由于生物硅酸盐能在矿化组织中形成羟基碳磷灰石,因此它在龋齿挑战下的珐琅质再矿化潜能方面显示出前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and effect of orodispersible film incorporated with Biosilicate for remineralization of dental enamel subjected to cariogenic and erosive challenge

Objectives

The objective of this in vitro study was to assess the efficiency of incorporating Biosilicate particles (30 and 50 mg) into an experimental orodispersible film and its efficacy in the remineralization process of bovine dental enamel under cariogenic and erosive challenges.

Methods

Ninety-nine intact incisors, devoid of cracks or fractures, yielding 198 samples (6 × 6 × 2 mm) via vestibular sectioning using a low-speed diamond disc under water cooling. After flattening the enamel surface with 600, 1200, and 2000 grit sandpaper, the samples were divided into two groups based on the challenges they underwent: cariogenic (0.1 M lactic acid at pH 5.0) or erosive (0.05 M citric acid solution at pH 2.3). Samples from each challenge were further categorized into 11 groups (n = 9) according to the duration of cariogenic (3, 7, and 14 days) or erosive (3, 7, and 10 days) challenge, along with positive control groups (fragments untreated with challenges and treated with different Biosilicate concentrations) and negative controls (fragments treated with artificial saliva for the same periods established for cariogenic and erosive challenges). Treatments with orodispersible films containing Biosilicate (30 and 50 mg) were administered for 2 min per day for 15 days.

Results

The highest remineralizing potential was observed in samples treated with Biosilicate after 14 days of cariogenic challenge, irrespective of the concentration tested. For samples subjected to erosive challenge, erosion time did not affect Biosilicate's remineralizing potential.

Conclusion

Biosilicate shows promise in terms of remineralizing potential in enamel subjected to cariogenic challenge due to its ability to form hydroxycarbonapatite in mineralized tissues.

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来源期刊
CiteScore
7.50
自引率
2.90%
发文量
199
审稿时长
12 months
期刊介绍: Journal of Biomedical Materials Research – Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices. It has the common focus of biomaterials applied to the human body and covers all disciplines where medical devices are used. Papers are published on biomaterials related to medical device development and manufacture, degradation in the body, nano- and biomimetic- biomaterials interactions, mechanics of biomaterials, implant retrieval and analysis, tissue-biomaterial surface interactions, wound healing, infection, drug delivery, standards and regulation of devices, animal and pre-clinical studies of biomaterials and medical devices, and tissue-biopolymer-material combination products. Manuscripts are published in one of six formats: • original research reports • short research and development reports • scientific reviews • current concepts articles • special reports • editorials Journal of Biomedical Materials Research – Part B: Applied Biomaterials is an official journal of the Society for Biomaterials, Japanese Society for Biomaterials, the Australasian Society for Biomaterials, and the Korean Society for Biomaterials. Manuscripts from all countries are invited but must be in English. Authors are not required to be members of the affiliated Societies, but members of these societies are encouraged to submit their work to the journal for consideration.
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