评估血浆嗜铬粒蛋白 A 测量在周期性促肾上腺皮质激素依赖性库欣综合征中的实用性。

IF 1.3 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2024-10-01 Epub Date: 2024-06-25 DOI:10.1507/endocrj.EJ24-0128
Keisuke Kakizawa, Miho Yamashita, Yuto Kawauchi, Akira Ikeya, Kenji Ohba, Akio Matsushita
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引用次数: 0

摘要

库欣综合征是一种以高皮质醇血症为特征的临床症状,具有明显的临床表现,部分患者伴有皮质醇的周期性分泌。周期性库欣综合征的临床表现可能模糊不清,其诊断往往具有挑战性。我们接诊了一名 72 岁的女性患者,她患有由肺类癌引起的周期性 ACTH 依赖性库欣综合征。由于低谷期较长,诊断具有挑战性,而且最初无法确定病灶。随后的随访计算机断层扫描发现了肺部病变,肺动脉取样证实了该病变引起的异位促肾上腺皮质激素分泌。尽管促肾上腺皮质激素的分泌高峰期很短(约一周),但手术切除肿瘤的免疫染色证实促肾上腺皮质激素呈阳性。有趣的是,血浆中储存的嗜铬粒蛋白 A 水平在高峰期和低谷期均有所升高。评估该患者的经验促使我们研究血浆嗜铬粒蛋白 A 作为 ACTH 依赖性库欣综合征诊断标志物的可能性。我们开展了一项回顾性研究,以确定血浆嗜铬粒蛋白 A 在包括本病例在内的 3 例异位 ACTH 综合征(EAS)患者和 6 例库欣病患者(CD)中的疗效。值得注意的是,EAS 患者的血浆嗜铬粒蛋白 A 水平高于 CD 患者。此外,本病例低谷期的嗜铬粒蛋白A水平低于高峰期,与CD患者相似。测量血浆嗜铬粒蛋白 A 水平有助于区分 EAS 和 CD。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluating the usefulness of plasma chromogranin A measurement in cyclic ACTH-dependent Cushing's syndrome.

Cushing's syndrome, a clinical condition characterized by hypercortisolemia, exhibits distinct clinical signs and is associated with cyclic cortisol secretion in some patients. The clinical presentation of cyclic Cushing's syndrome can be ambiguous and its diagnosis is often challenging. We experienced a 72-year-old woman with cyclic ACTH-dependent Cushing's syndrome caused by a pulmonary carcinoid tumor. Diagnosis was challenging because of the extended trough periods, and the responsible lesion was initially unidentified. A subsequent follow-up computed tomography revealed a pulmonary lesion, and ectopic ACTH secretion from this lesion was confirmed by pulmonary artery sampling. Despite the short peak secretion period of ACTH (approximately one week), immunostaining of the surgically removed tumor confirmed ACTH positivity. Interestingly, stored plasma chromogranin A levels were elevated during both peak and trough periods. The experience in evaluating this patient prompted us to investigate the potential use of plasma chromogranin A as a diagnostic marker of ACTH-dependent Cushing's syndrome. A retrospective study was conducted to determine the efficacy of plasma chromogranin A in three patients with ectopic ACTH syndrome (EAS), including the present case, and six patients with Cushing's disease (CD) who visited our hospital between 2018 and 2021. Notably, plasma chromogranin A levels were higher in patients with EAS than in those with CD. Additionally, a chromogranin A level in the present case during the trough phase was lower than that in the peak phase, and was similar to those in CD patients. The measurement of plasma chromogranin A levels could aid in differentiating EAS from CD.

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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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