Rossella Messina , Briana Mezuk , Simona Rosa , Marica Iommi , Maria Pia Fantini , Jacopo Lenzi , Paolo Di Bartolo
{"title":"2 型糖尿病发病年龄是痴呆症的风险因素:一项为期 13 年的回顾性队列研究。","authors":"Rossella Messina , Briana Mezuk , Simona Rosa , Marica Iommi , Maria Pia Fantini , Jacopo Lenzi , Paolo Di Bartolo","doi":"10.1016/j.diabres.2024.111760","DOIUrl":null,"url":null,"abstract":"<div><h3>Aims</h3><p>To examine whether age at type 2 diabetes onset is an independent predictor of dementia risk.</p></div><div><h3>Methods</h3><p>Retrospective cohort drawn from healthcare administrative records of all inhabitants within Romagna’s catchment area, Italy, with an estimated onset of type 2 diabetes in 2008–2017 and aged ≥ 55, with follow-up until 2020. Time to dementia or censoring was estimated with the Kaplan–Meier method, using diabetes onset as the time origin. Age groups were compared with the log-rank test. Multivariable competing-risks analysis was used to assess predictors of dementia.</p></div><div><h3>Results</h3><p>In patients aged ≥ 75 years, dementia-free survival (DFS) declined to below 90 % within five years and linearly decreased to 68.8 % until the end of follow-up. In contrast, DFS for those aged 55–64 years showed a marginal decrease, reaching 97.4 % after 13 years. Competing-risks regression showed that individuals aged ≥ 75 and 65–74 had a significantly higher risk of dementia compared to those aged 55–64 years. Having more comorbidities at diabetes onset and initial treatment with ≥ 2 antidiabetics were clinical predictors.</p></div><div><h3>Conclusions</h3><p>Later age at onset of diabetes is strongly associated with dementia. A better understanding of the diabetes–dementia relationship is needed to inform strategies for promoting specific healthcare pathways.</p></div>","PeriodicalId":11249,"journal":{"name":"Diabetes research and clinical practice","volume":null,"pages":null},"PeriodicalIF":6.1000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168822724006703/pdfft?md5=6056f3769a8c3732cff341e50371a124&pid=1-s2.0-S0168822724006703-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Age of type 2 diabetes onset as a risk factor for dementia: A 13-year retrospective cohort study\",\"authors\":\"Rossella Messina , Briana Mezuk , Simona Rosa , Marica Iommi , Maria Pia Fantini , Jacopo Lenzi , Paolo Di Bartolo\",\"doi\":\"10.1016/j.diabres.2024.111760\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aims</h3><p>To examine whether age at type 2 diabetes onset is an independent predictor of dementia risk.</p></div><div><h3>Methods</h3><p>Retrospective cohort drawn from healthcare administrative records of all inhabitants within Romagna’s catchment area, Italy, with an estimated onset of type 2 diabetes in 2008–2017 and aged ≥ 55, with follow-up until 2020. Time to dementia or censoring was estimated with the Kaplan–Meier method, using diabetes onset as the time origin. Age groups were compared with the log-rank test. Multivariable competing-risks analysis was used to assess predictors of dementia.</p></div><div><h3>Results</h3><p>In patients aged ≥ 75 years, dementia-free survival (DFS) declined to below 90 % within five years and linearly decreased to 68.8 % until the end of follow-up. In contrast, DFS for those aged 55–64 years showed a marginal decrease, reaching 97.4 % after 13 years. Competing-risks regression showed that individuals aged ≥ 75 and 65–74 had a significantly higher risk of dementia compared to those aged 55–64 years. Having more comorbidities at diabetes onset and initial treatment with ≥ 2 antidiabetics were clinical predictors.</p></div><div><h3>Conclusions</h3><p>Later age at onset of diabetes is strongly associated with dementia. A better understanding of the diabetes–dementia relationship is needed to inform strategies for promoting specific healthcare pathways.</p></div>\",\"PeriodicalId\":11249,\"journal\":{\"name\":\"Diabetes research and clinical practice\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0168822724006703/pdfft?md5=6056f3769a8c3732cff341e50371a124&pid=1-s2.0-S0168822724006703-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Diabetes research and clinical practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0168822724006703\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes research and clinical practice","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0168822724006703","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Age of type 2 diabetes onset as a risk factor for dementia: A 13-year retrospective cohort study
Aims
To examine whether age at type 2 diabetes onset is an independent predictor of dementia risk.
Methods
Retrospective cohort drawn from healthcare administrative records of all inhabitants within Romagna’s catchment area, Italy, with an estimated onset of type 2 diabetes in 2008–2017 and aged ≥ 55, with follow-up until 2020. Time to dementia or censoring was estimated with the Kaplan–Meier method, using diabetes onset as the time origin. Age groups were compared with the log-rank test. Multivariable competing-risks analysis was used to assess predictors of dementia.
Results
In patients aged ≥ 75 years, dementia-free survival (DFS) declined to below 90 % within five years and linearly decreased to 68.8 % until the end of follow-up. In contrast, DFS for those aged 55–64 years showed a marginal decrease, reaching 97.4 % after 13 years. Competing-risks regression showed that individuals aged ≥ 75 and 65–74 had a significantly higher risk of dementia compared to those aged 55–64 years. Having more comorbidities at diabetes onset and initial treatment with ≥ 2 antidiabetics were clinical predictors.
Conclusions
Later age at onset of diabetes is strongly associated with dementia. A better understanding of the diabetes–dementia relationship is needed to inform strategies for promoting specific healthcare pathways.
期刊介绍:
Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.