乙氧基曼松酮 G 的治疗潜力:对其在乳腺癌、结直肠癌和非小细胞肺癌中抗癌作用的全面探索。

IF 3.3 3区 生物学 Q3 CELL BIOLOGY
Amna Fayyaz, Mahnoor Basit, Andleeb Farooq, Tooba Khan, Umama Ayub, Somia Khan, Muhammad Armaghan,  Mati-ur-Rahman, Muhammad Ammad, Dietrich Büsselberg, Khushbukhat Khan, Solomon Habtemariam, Javad Sharifi-Rad
{"title":"乙氧基曼松酮 G 的治疗潜力:对其在乳腺癌、结直肠癌和非小细胞肺癌中抗癌作用的全面探索。","authors":"Amna Fayyaz,&nbsp;Mahnoor Basit,&nbsp;Andleeb Farooq,&nbsp;Tooba Khan,&nbsp;Umama Ayub,&nbsp;Somia Khan,&nbsp;Muhammad Armaghan,&nbsp; Mati-ur-Rahman,&nbsp;Muhammad Ammad,&nbsp;Dietrich Büsselberg,&nbsp;Khushbukhat Khan,&nbsp;Solomon Habtemariam,&nbsp;Javad Sharifi-Rad","doi":"10.1002/cbin.12207","DOIUrl":null,"url":null,"abstract":"<p>Mansonone G (MG), a 1,2-naphthoquinones with antiestrogenic, antimicrobial, and anti-adipogenic activities, is derived from the heartwood of <i>Mansonia gagei</i> Drumm. Ethoxy mansonone G (EMG), an essential derivative of MG, has anticancer and antioxidant agent. EMG also has antiestrogen activity and is demonstrated to lower estrogen receptor expression in endocrine-resistant cells. EMG significantly inhibits cell division, invasion, and anchorage-dependent growth in all cancer types. Through the stimulation of the tumor protein (p53) and extracellular signal-regulated kinase (ERK) signaling cascades, it also causes apoptosis. Moreover, it manifests its anti-cancerous effects in toll-like receptor pathways, c-Jun N-terminal kinase (c-JNK), and nuclear factor kappa B (NF-κB). EMG inhibits the phosphorylation of glycogen synthase kinase (GSK3), Erk, protein kinase B (Akt), and mammalian target of rapamycin (mTOR). By interfering with molecular cascades, EMG significantly reduces the metabolism of cancer cells. This paper focuses on the potential use of EMG in cancer treatment. Moreover, it states the methodology by which specific assays establish the anti-cancerous role of EMG. Breast cancer, non-small cell lung cancer, and colorectal cancer are only a few of the cancers for which EMG was shown to be effective. Through further research, EMG may be developed as a therapeutic solution to complications caused by cancer. This study presents EMG as a novel candidate for cancer therapy, offering a unique combination of pharmacological advantages and mechanistic insights that warrant further exploration and development toward addressing the complexities of cancer treatment.</p>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"48 9","pages":"1229-1239"},"PeriodicalIF":3.3000,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Therapeutic potential of ethoxy mansonone G: A comprehensive exploration of its anticancer actions in breast cancer, colorectal cancer, and non-small cell lung carcinoma\",\"authors\":\"Amna Fayyaz,&nbsp;Mahnoor Basit,&nbsp;Andleeb Farooq,&nbsp;Tooba Khan,&nbsp;Umama Ayub,&nbsp;Somia Khan,&nbsp;Muhammad Armaghan,&nbsp; Mati-ur-Rahman,&nbsp;Muhammad Ammad,&nbsp;Dietrich Büsselberg,&nbsp;Khushbukhat Khan,&nbsp;Solomon Habtemariam,&nbsp;Javad Sharifi-Rad\",\"doi\":\"10.1002/cbin.12207\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Mansonone G (MG), a 1,2-naphthoquinones with antiestrogenic, antimicrobial, and anti-adipogenic activities, is derived from the heartwood of <i>Mansonia gagei</i> Drumm. Ethoxy mansonone G (EMG), an essential derivative of MG, has anticancer and antioxidant agent. EMG also has antiestrogen activity and is demonstrated to lower estrogen receptor expression in endocrine-resistant cells. EMG significantly inhibits cell division, invasion, and anchorage-dependent growth in all cancer types. Through the stimulation of the tumor protein (p53) and extracellular signal-regulated kinase (ERK) signaling cascades, it also causes apoptosis. Moreover, it manifests its anti-cancerous effects in toll-like receptor pathways, c-Jun N-terminal kinase (c-JNK), and nuclear factor kappa B (NF-κB). EMG inhibits the phosphorylation of glycogen synthase kinase (GSK3), Erk, protein kinase B (Akt), and mammalian target of rapamycin (mTOR). By interfering with molecular cascades, EMG significantly reduces the metabolism of cancer cells. This paper focuses on the potential use of EMG in cancer treatment. Moreover, it states the methodology by which specific assays establish the anti-cancerous role of EMG. Breast cancer, non-small cell lung cancer, and colorectal cancer are only a few of the cancers for which EMG was shown to be effective. Through further research, EMG may be developed as a therapeutic solution to complications caused by cancer. This study presents EMG as a novel candidate for cancer therapy, offering a unique combination of pharmacological advantages and mechanistic insights that warrant further exploration and development toward addressing the complexities of cancer treatment.</p>\",\"PeriodicalId\":9806,\"journal\":{\"name\":\"Cell Biology International\",\"volume\":\"48 9\",\"pages\":\"1229-1239\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell Biology International\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/cbin.12207\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biology International","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbin.12207","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

曼松酮 G(MG)是从 Mansonia gagei Drumm 的心材中提取的一种 1,2-萘醌类化合物,具有抗雌激素、抗菌和抗脂肪生成的活性。乙氧基曼松酮 G(EMG)是 MG 的一种重要衍生物,具有抗癌和抗氧化作用。EMG 还具有抗雌激素活性,可降低抗内分泌细胞中雌激素受体的表达。EMG 能明显抑制所有癌症类型的细胞分裂、侵袭和锚定依赖性生长。通过刺激肿瘤蛋白(p53)和细胞外信号调节激酶(ERK)信号级联,它还能导致细胞凋亡。此外,它还能在类收费受体通路、c-Jun N-末端激酶(c-JNK)和核因子卡巴B(NF-κB)中发挥抗癌作用。EMG可抑制糖原合酶激酶(GSK3)、Erk、蛋白激酶B(Akt)和哺乳动物雷帕霉素靶标(mTOR)的磷酸化。通过干扰分子级联,EMG 能显著降低癌细胞的新陈代谢。本文重点介绍了 EMG 在癌症治疗中的潜在用途。此外,本文还阐述了通过特定测定确定 EMG 抗癌作用的方法。乳腺癌、非小细胞肺癌和结肠直肠癌只是 EMG 被证明有效的几种癌症。通过进一步研究,EMG 有可能被开发成一种治疗癌症并发症的方法。本研究将 EMG 作为癌症治疗的新型候选药物,提供了药理优势和机理见解的独特组合,值得进一步探索和开发,以解决癌症治疗的复杂性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic potential of ethoxy mansonone G: A comprehensive exploration of its anticancer actions in breast cancer, colorectal cancer, and non-small cell lung carcinoma

Mansonone G (MG), a 1,2-naphthoquinones with antiestrogenic, antimicrobial, and anti-adipogenic activities, is derived from the heartwood of Mansonia gagei Drumm. Ethoxy mansonone G (EMG), an essential derivative of MG, has anticancer and antioxidant agent. EMG also has antiestrogen activity and is demonstrated to lower estrogen receptor expression in endocrine-resistant cells. EMG significantly inhibits cell division, invasion, and anchorage-dependent growth in all cancer types. Through the stimulation of the tumor protein (p53) and extracellular signal-regulated kinase (ERK) signaling cascades, it also causes apoptosis. Moreover, it manifests its anti-cancerous effects in toll-like receptor pathways, c-Jun N-terminal kinase (c-JNK), and nuclear factor kappa B (NF-κB). EMG inhibits the phosphorylation of glycogen synthase kinase (GSK3), Erk, protein kinase B (Akt), and mammalian target of rapamycin (mTOR). By interfering with molecular cascades, EMG significantly reduces the metabolism of cancer cells. This paper focuses on the potential use of EMG in cancer treatment. Moreover, it states the methodology by which specific assays establish the anti-cancerous role of EMG. Breast cancer, non-small cell lung cancer, and colorectal cancer are only a few of the cancers for which EMG was shown to be effective. Through further research, EMG may be developed as a therapeutic solution to complications caused by cancer. This study presents EMG as a novel candidate for cancer therapy, offering a unique combination of pharmacological advantages and mechanistic insights that warrant further exploration and development toward addressing the complexities of cancer treatment.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Cell Biology International
Cell Biology International 生物-细胞生物学
CiteScore
7.60
自引率
0.00%
发文量
208
审稿时长
1 months
期刊介绍: Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect. These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信