糖尿病足溃疡患者接受胫骨皮质横向运输手术治疗与血小板淋巴细胞比率和单核细胞中性粒细胞比率的相关性分析。

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Sijie Yang, Kaixiang Pan, Qikai Hua, Hongjie Su, Jun Hou, Kaibing Liu, Jinmin Zhao
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引用次数: 0

摘要

背景:糖尿病足溃疡(DFU)是糖尿病晚期最严重的并发症之一。胫骨皮质横向搬运(TTT)手术是目前治疗糖尿病足溃疡的主要方法。这种手术干预有望加快 DFU 伤口愈合并降低截肢率,而炎症反应的缓解起到了关键作用。在这项研究中,我们旨在探讨炎症与 TTT 手术之间的相关性,其总体目标是促进临床实践中对预后的快速评估:目的:DFU 的严重程度与临床检测结果之间的相关性仍不明确。我们设计了一个临床预测模型,利用直接有效的临床指标来探索 DFU 严重程度与 TTT 手术疗效之间的联系:材料:通过追踪在广西医科大学第一附属医院(中国南宁)接受 TTT 手术的住院 DFU 患者,收集临床数据和检查结果。通过逻辑回归和最小绝对收缩和选择算子(LASSO)回归分析,确定了与 DFU 严重程度和术后伤口愈合时间相关的指标。随后,建立了临床预测模型。最后,这两组指标的交叉点揭示了与伤口严重程度和术后愈合时间相关的因素:我们的研究由 202 名患者组成,他们根据瓦格纳的分级分为两组。通过学生 t 检验、LASSO 回归和逻辑回归分析,我们确定了 3 个表明 DFU 严重程度的因素:血小板淋巴细胞比值 (PLR)、混合淋巴细胞反应 (MLR) 和血红蛋白 (HGB)。单变量 COX 回归分析显示,白细胞(WBC)、中性粒细胞(NEUT)、单核细胞(MO)、血小板与淋巴细胞比值(PLR)、混合淋巴细胞比值(MLR)、中性粒细胞与淋巴细胞比值(NLR)、红细胞沉降率(ESR)、年龄、淋巴细胞(LY)、单核细胞与中性粒细胞比值(MNR)、尿酸(UA)和白蛋白(ALB)等 12 个因素与术后愈合持续时间相关。最终,我们在这两个数据集的交叉点上确定了两个因素,即 PLR 和 MNR:结论:血小板淋巴细胞比值和 MNR 被确定为与 TTT 手术后 DFU 严重程度和预后相关的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation analysis of patients with diabetic foot ulcers treated with tibial cortex transverse transport surgery and platelet-to-lymphocyte ratio and monocyte-to-neutrophil ratio.

Background: Diabetic foot ulcers (DFUs) represent one of the most severe late-stage complications of diabetes. Tibial cortex transverse transport (TTT) surgery stands as the prevailing method for addressing DFUs. This surgical intervention holds the promise of expediting DFU wound healing and diminishing the rate of amputations, with the mitigation of inflammatory responses playing a pivotal role. In this study, we aim to explore the correlation between inflammation and TTT surgery, with the overarching goal of facilitating swift prognostic assessments in clinical practice.

Objectives: The correlation between the severity of DFUs and clinical test results remains ambiguous. A clinical prediction model was devised to explore the connection between DFU severity and the efficacy of TTT surgery, utilizing straightforward and efficient clinical indicators.

Material and methods: Clinical data and examination results were gathered by tracking hospitalized DFU patients who underwent TTT surgery at the First Affiliated Hospital of Guangxi Medical University (Nanning, China). Indicators associated with DFU severity and wound healing time post-surgery were identified through logistic regression and least absolute shrinkage and selection operator (LASSO) regression analyses. Subsequently, a clinical prediction model was constructed. Finally, the intersection of these 2 sets of indicators revealed factors correlated with wound severity and post-operative healing duration.

Results: Our study was comprised of 202 patients who were categorized into 2 groups based on Wagner's grading classifications. Utilizing Student's t-tests, LASSO regression and logistic regression analyses, we identified 3 factors indicative of DFU severity: platelet-to-lymphocyte ratio (PLR), mixed lymphocyte reaction (MLR) and hemoglobin (HGB). Univariate COX regression analysis revealed 12 factors such as: white blood cells (WBC), neutrophils (NEUT), monocytes (MO), PLR, MLR, neutrophil-to-lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), age, lymphocytes (LY), monocyte-to-neutrophil ratio (MNR), uric acid (UA), and albumin (ALB) associated with the postoperative healing duration. Ultimately, we identified 2 factors, PLR and MNR, at the intersection of these 2 datasets.

Conclusions: Platelet-to-lymphocyte ratio and MNR were identified as factors associated with both the severity of DFUs and the prognosis following TTT surgery.

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来源期刊
Advances in Clinical and Experimental Medicine
Advances in Clinical and Experimental Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.70
自引率
4.80%
发文量
153
审稿时长
6-12 weeks
期刊介绍: Advances in Clinical and Experimental Medicine has been published by the Wroclaw Medical University since 1992. Establishing the medical journal was the idea of Prof. Bogumił Halawa, Chair of the Department of Cardiology, and was fully supported by the Rector of Wroclaw Medical University, Prof. Zbigniew Knapik. Prof. Halawa was also the first editor-in-chief, between 1992-1997. The journal, then entitled "Postępy Medycyny Klinicznej i Doświadczalnej", appeared quarterly. Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff. Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj. Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker. The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition. In 2010 the journal obtained Impact Factor which is now 1.179 pts. Articles published in the journal are worth 15 points among Polish journals according to the Polish Committee for Scientific Research and 169.43 points according to the Index Copernicus. Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.
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