红细胞分布宽度/血清白蛋白比值与糖尿病肾病的关系

IF 3 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Jiaqi Chen, Daguan Zhang, Depu Zhou, Zhijuan Dai, Jie Wang
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引用次数: 0

摘要

背景:以往的研究表明,红细胞分布宽度(RDW)/血清白蛋白比值(RA)是一种综合性的新型炎症标志物。RA与多种疾病的临床结果相关,但RDW/RA在糖尿病肾病(DKD)评估中的临床价值尚未阐明。我们研究了糖尿病 RA 和 DKD 之间的联系,同时控制了各种可能的混杂因素:我们对第二附属医院和育英儿童医院的全国健康与营养调查(NHANES:2009-2018 年)数据库以及温州医科大学(WMU)数据库进行了回顾性队列分析。采用多变量逻辑回归分析评估RA与DKD之间的关系:本研究共纳入了来自NHANES数据库(n = 2839)和温州医科大学数据库(n = 1412)的4513名糖尿病患者;NHANES数据库中有974名患者被诊断为DKD,温州医科大学数据库中有462名患者被诊断为DKD。在NHANES队列中,RA水平较高的糖尿病(DM)患者罹患DKD的风险较高(几率比=1.461,95%置信区间:1.250-1.707,P < 0.00001)。经过混杂因素调整和倾向得分匹配(PSM)分析后,显示的 RA 水平均与 DKD 有独立联系(pAdjust = 0.00994,pPSM = 0.02889)。WMU队列中也观察到了类似的结果(p 结论):研究发现,RA 是糖尿病患者 DKD 的独立预测指标。RA是一种具有成本效益且易于获得的生物标志物,可能具有对DKD进行风险分层的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association between red cell distribution width/serum albumin ratio and diabetic kidney disease

Association between red cell distribution width/serum albumin ratio and diabetic kidney disease

Background

Previous studies have shown that the red cell distribution width (RDW)/serum albumin ratio (RA) is an integrative and new inflammatory marker. RA is associated with clinical outcomes in a variety of diseases, but the clinical value of RDW/RA in the assessment of diabetic kidney disease (DKD) has not been elucidated. We examined the link between diabetic RA and DKD while controlling for a wide variety of possible confounders.

Methods

Retrospective cohort analysis of the National Health and Nutrition Examination Survey (NHANES: 2009–2018) database from the Second Affiliated Hospital and Yuying Children's Hospital and the Wenzhou Medical University (WMU) database was conducted. Multivariate logistic regression analysis was used to assess the association between RA and DKD.

Results

Overall, 4513 diabetic patients from the NHANES database (n = 2839) and the WMU (n = 1412) were included in this study; 974 patients were diagnosed with DKD in NHANES and 462 in WMU. In the NHANES cohort, diabetes mellitus (DM) patients with higher RA level had a higher risk of DKD (odds ratio = 1.461, 95% confidence interval: 1.250–1.707, p < 0.00001). After adjusting for confounders and propensity score-matched (PSM) analysis, both shown RA levels were independently linked to DKD (pAdjust = 0.00994, pPSM = 0.02889). Similar results were also observed in the WMU cohort (p < 0.00001).

Conclusions

The study observes that the RA was an independent predictor of DKD in DM patients. The RA, a biomarker that is cost-effective and easy-to-access, may have potential for risk stratification of DKD.

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来源期刊
Journal of Diabetes
Journal of Diabetes ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
2.20%
发文量
94
审稿时长
>12 weeks
期刊介绍: Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.
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