Ziwei Hu, Wei Wang, Ying Lin, Hui Guo, Yiwen Chen, Junjie Wang, Feng Yu, Lang Rao, Zhijin Fan
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引用次数: 0
摘要
冠状病毒肺炎(COVID-19)等新发传染病给全球健康带来了重大挑战,广泛影响着人类社会和经济。作为 COVID-19 诊断和治疗的重要生物医学工具,细胞外囊泡(EVs)已显示出巨大的潜力。然而,由于天然囊泡在性能和滴度方面的限制,其临床应用仍然有限。尽管如此,EV启发策略正受到越来越多的关注。值得注意的是,受EV启发的生物仿生囊泡具有特异性受体,可以充当 "特洛伊木马",阻止病毒感染宿主细胞。基因工程可以增强这些囊泡,使其携带更多的受体,从而大大提高其吸收新型冠状病毒的特异性。此外,生物仿生囊泡还能从母细胞中继承大量细胞因子受体,从而吸附促炎细胞因子,有效缓解 "细胞因子风暴"。总之,这种受 EV 启发的策略为治疗新出现的传染性疾病提供了新途径。在此,本综述系统地总结了目前 EV 启发策略在 COVID-19 诊断和治疗中的应用。此外,还讨论了与 EV 启发策略的临床实施相关的现状和挑战。这篇综述的目的是为 EV 启发策略的设计提供新的见解,并扩大其在抗击新发传染病中的应用。本文受版权保护。保留所有权利。
Extracellular Vesicle-Inspired Therapeutic Strategies for the COVID-19.
Emerging infectious diseases like coronavirus pneumonia (COVID-19) present significant challenges to global health, extensively affecting both human society and the economy. Extracellular vesicles (EVs) have demonstrated remarkable potential as crucial biomedical tools for COVID-19 diagnosis and treatment. However, due to limitations in the performance and titer of natural vesicles, their clinical use remains limited. Nonetheless, EV-inspired strategies are gaining increasing attention. Notably, biomimetic vesicles, inspired by EVs, possess specific receptors that can act as "Trojan horses," preventing the virus from infecting host cells. Genetic engineering can enhance these vesicles by enabling them to carry more receptors, significantly increasing their specificity for absorbing the novel coronavirus. Additionally, biomimetic vesicles inherit numerous cytokine receptors from parent cells, allowing them to effectively mitigate the "cytokine storm" by adsorbing pro-inflammatory cytokines. Overall, this EV-inspired strategy offers new avenues for the treatment of emerging infectious diseases. Herein, this review systematically summarizes the current applications of EV-inspired strategies in the diagnosis and treatment of COVID-19. The current status and challenges associated with the clinical implementation of EV-inspired strategies are also discussed. The goal of this review is to provide new insights into the design of EV-inspired strategies and expand their application in combating emerging infectious diseases.
期刊介绍:
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.