载姜黄素的 PLGA-LEC/F127 混合纳米粒子及其对单核细胞的调节作用

Nanomedicine (London, England) Pub Date : 2024-06-20 Epub Date: 2024-06-26 DOI:10.1080/17435889.2024.2357530
Jennifer T Cruz, Karen Álvarez, Víctor H Orozco, Mauricio Rojas, Raul A Morales-Luckie, Luis F Giraldo
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引用次数: 0

摘要

目的:研究表面活性剂类型对姜黄素负载(CUR)PLGA纳米颗粒(NPs)调节单核细胞功能的影响。材料与方法:采用纳米沉淀法,以 Pluronic F127(F127)和/或卵磷脂(LEC)为表面活性剂设计 PLGA NPs。结果表明NPs的Z-平均值为0.128 MPa,在4°C条件下储存稳定,ζ电位∼-40 mV,多分散指数为94%。PLGA-LEC/F127 NPs 表现出良好的物理化学和纳米力学性能。这些 NPs 主要被单核细胞结合和内化,抑制了单核细胞诱导的活性氧产生,并降低了单核细胞调节 T 细胞增殖的能力。结论这些结果证明了这些 NPs 在靶向治疗方面的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PLGA-LEC/F127 hybrid nanoparticles loaded with curcumin and their modulatory effect on monocytes.

Aim: To investigate the effect of surfactant type on curcumin-loaded (CUR) PLGA nanoparticles (NPs) to modulate monocyte functions. Materials & methods: The nanoprecipitation method was used, and PLGA NPs were designed using Pluronic F127 (F127) and/or lecithin (LEC) as surfactants. Results: The Z-average of the NPs was <200 nm, they had a spherical shape, Derjaguin-Muller-Toporov modulus >0.128 MPa, they were stable during storage at 4°C, ζ-potential ∼-40 mV, polydispersity index <0.26 and % EE of CUR >94%. PLGA-LEC/F127 NPs showed favorable physicochemical and nanomechanical properties. These NPs were bound and internalized mainly by monocytes, suppressed monocyte-induced reactive oxygen species production, and decreased the ability of monocytes to modulate T-cell proliferation. Conclusion: These results demonstrate the potential of these NPs for targeted therapy.

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