脑卒中后最初几周经颅直流电刺激的效果:一项试验性随机研究。

IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL
Einstein-Sao Paulo Pub Date : 2024-06-24 eCollection Date: 2024-01-01 DOI:10.31744/einstein_journal/2024AO0450
Marcela Tengler Carvalho Takahashi, Joana Bisol Balardin, Paulo Rodrigo Bazán, Danielle de Sá Boasquevisque, Edson Amaro Junior, Adriana Bastos Conforto
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引用次数: 0

摘要

研究目的本研究旨在评估脑卒中后接受阴性经颅直流电刺激后上肢运动障碍的改变以及运动区域之间的连接性:方法:比较了13名患者(主动=6;假性=7)在接受6次阴极经颅直流电刺激之前和之后的Fugl-Meyer评估评分、未受影响半球和受影响半球初级运动皮层之间的连接性以及未受影响半球初级运动皮层和前运动皮层之间的连接性的变化;这种方式针对中风后早期未受影响半球的初级运动皮层:结果:在临床上观察到的 Fugl-Meyer 评估评分差异(≥9 分),假体组多于活性组。组间 Fugl-Meyer 评估得分的变化差异无统计学意义(Mann-Whitney 检验,P=0.133)。在积极组和无效组中,分别有 5/6 和 2/7 的受影响半球和未受影响半球初级运动皮层的 ROI 与 ROI 之间的相关性在治疗后有所增加。在上述区域之间的连接性改变方面,组间差异无统计学意义。与积极组相比,无效组的运动表现更频繁地得到提高:这项假设性研究的结果表明,连通性的增强可能不会转化为中风后的早期临床获益,这对设计更大规模的队列研究以探索这种干预措施的影响机制至关重要。ClinicalTrials.gov Identifier:NCT02455427。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of transcranial direct current stimulation in the initial weeks post-stroke: a pilot randomized study.

Objective: This study aimed at assessing the alterations in upper limb motor impairment and connectivity between motor areas following the post-stroke delivery of cathodal transcranial direct current stimulation sessions.

Methods: Modifications in the Fugl-Meyer Assessment scores, connectivity between the primary motor cortex of the unaffected and affected hemispheres, and between the primary motor and premotor cortices of the unaffected hemisphere were compared prior to and following six sessions of cathodal transcranial direct current stimulation application in 13 patients (active = 6; sham = 7); this modality targets the primary motor cortex of the unaffected hemisphere early after a stroke.

Results: Clinically relevant distinctions in Fugl-Meyer Assessment scores (≥9 points) were observed more frequently in the Sham Group than in the Active Group. Between-group differences in the alterations in Fugl-Meyer Assessment scores were not statistically significant (Mann-Whitney test, p=0.133). ROI-to-ROI correlations between the primary motor cortices of the affected and unaffected hemispheres post-therapeutically increased in 5/6 and 2/7 participants in the Active and Sham Groups, respectively. Between-group differences in modifications in connectivity between the aforementioned areas were not statistically significant. Motor performance enhancements were more frequent in the Sham Group compared to the Active Group.

Conclusion: The results of this hypothesis-generating investigation suggest that heightened connectivity may not translate into early clinical benefits following a stroke and will be crucial in designing larger cohort studies to explore mechanisms underlying the impacts of this intervention. ClinicalTrials.gov Identifier: NCT02455427.

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来源期刊
Einstein-Sao Paulo
Einstein-Sao Paulo MEDICINE, GENERAL & INTERNAL-
CiteScore
2.00
自引率
0.00%
发文量
210
审稿时长
38 weeks
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