Grace Baldwin, Jack Tracy, Filippos Vingopoulos, Mary Munsell, Cade Bennett, Jocelyn Marie Rodriguez, Hanna Choi, Itika Garg, Rachel Tandias, Hannah Wescott, Matthew J Finn, Peyman Razavi, Augustine Bannerman, Rebecca Zeng, Demetrios G Vavvas, Deeba Husain, Leo A Kim, Nimesh A Patel, John B Miller
{"title":"与视力相比，对比敏感度能更好地反映健康眼睛的宽视场扫源光学相干断层扫描血管成像指标。","authors":"Grace Baldwin, Jack Tracy, Filippos Vingopoulos, Mary Munsell, Cade Bennett, Jocelyn Marie Rodriguez, Hanna Choi, Itika Garg, Rachel Tandias, Hannah Wescott, Matthew J Finn, Peyman Razavi, Augustine Bannerman, Rebecca Zeng, Demetrios G Vavvas, Deeba Husain, Leo A Kim, Nimesh A Patel, John B Miller","doi":"10.3928/23258160-20240411-01","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>To evaluate the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) and visual function in healthy eyes.</p><p><strong>Patients and methods: </strong>Fifty-seven eyes of 45 patients were evaluated with visual acuity (VA), contrast sensitivity (CS), and WF SS-OCTA (3 × 3, 6 × 6, and 12 × 12 mm images) on the same day. Mixed-effects multivariable regression analyses were performed.</p><p><strong>Results: </strong>Contrast sensitivity metrics, including CS between 6 to 18 cycles per degree (cpd) and area under the logarithm CS function, were significantly associated with vessel density (VD) and vessel skeletonized density (VSD), whereas VA was not. The largest effect size was between CS at 18 cpd and VD (β = 0.41, <i>P</i> = 0.007) and VSD (β = 0.42, <i>P</i> = 0.006) on 12 × 12 mm images.</p><p><strong>Conclusions: </strong>Reduced VSD and VD on WF SSOCTA was significantly associated with decreased CS, whereas VA was not. These results suggest CS could serve as a screening tool for early stage retinal and neurologic disorders. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:494-502.]</b>.</p>","PeriodicalId":19679,"journal":{"name":"Ophthalmic surgery, lasers & imaging retina","volume":" ","pages":"494-502"},"PeriodicalIF":0.9000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Contrast Sensitivity Better Reflects Wide-Field Swept-Source Optical Coherence Tomography Angiography Vascular Metrics Among Healthy Eyes Compared to Visual Acuity.\",\"authors\":\"Grace Baldwin, Jack Tracy, Filippos Vingopoulos, Mary Munsell, Cade Bennett, Jocelyn Marie Rodriguez, Hanna Choi, Itika Garg, Rachel Tandias, Hannah Wescott, Matthew J Finn, Peyman Razavi, Augustine Bannerman, Rebecca Zeng, Demetrios G Vavvas, Deeba Husain, Leo A Kim, Nimesh A Patel, John B Miller\",\"doi\":\"10.3928/23258160-20240411-01\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objective: </strong>To evaluate the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) and visual function in healthy eyes.</p><p><strong>Patients and methods: </strong>Fifty-seven eyes of 45 patients were evaluated with visual acuity (VA), contrast sensitivity (CS), and WF SS-OCTA (3 × 3, 6 × 6, and 12 × 12 mm images) on the same day. Mixed-effects multivariable regression analyses were performed.</p><p><strong>Results: </strong>Contrast sensitivity metrics, including CS between 6 to 18 cycles per degree (cpd) and area under the logarithm CS function, were significantly associated with vessel density (VD) and vessel skeletonized density (VSD), whereas VA was not. The largest effect size was between CS at 18 cpd and VD (β = 0.41, <i>P</i> = 0.007) and VSD (β = 0.42, <i>P</i> = 0.006) on 12 × 12 mm images.</p><p><strong>Conclusions: </strong>Reduced VSD and VD on WF SSOCTA was significantly associated with decreased CS, whereas VA was not. These results suggest CS could serve as a screening tool for early stage retinal and neurologic disorders. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2024;55:494-502.]</b>.</p>\",\"PeriodicalId\":19679,\"journal\":{\"name\":\"Ophthalmic surgery, lasers & imaging retina\",\"volume\":\" \",\"pages\":\"494-502\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmic surgery, lasers & imaging retina\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3928/23258160-20240411-01\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/1 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmic surgery, lasers & imaging retina","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3928/23258160-20240411-01","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/1 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Contrast Sensitivity Better Reflects Wide-Field Swept-Source Optical Coherence Tomography Angiography Vascular Metrics Among Healthy Eyes Compared to Visual Acuity.
Background and objective: To evaluate the association between widefield swept-source optical coherence tomography angiography (WF SS-OCTA) and visual function in healthy eyes.
Patients and methods: Fifty-seven eyes of 45 patients were evaluated with visual acuity (VA), contrast sensitivity (CS), and WF SS-OCTA (3 × 3, 6 × 6, and 12 × 12 mm images) on the same day. Mixed-effects multivariable regression analyses were performed.
Results: Contrast sensitivity metrics, including CS between 6 to 18 cycles per degree (cpd) and area under the logarithm CS function, were significantly associated with vessel density (VD) and vessel skeletonized density (VSD), whereas VA was not. The largest effect size was between CS at 18 cpd and VD (β = 0.41, P = 0.007) and VSD (β = 0.42, P = 0.006) on 12 × 12 mm images.
Conclusions: Reduced VSD and VD on WF SSOCTA was significantly associated with decreased CS, whereas VA was not. These results suggest CS could serve as a screening tool for early stage retinal and neurologic disorders. [Ophthalmic Surg Lasers Imaging Retina 2024;55:494-502.].
期刊介绍：
OSLI Retina focuses exclusively on retinal diseases, surgery and pharmacotherapy. OSLI Retina will offer an expedited submission to publication effort of peer-reviewed clinical science and case report articles. The front of the journal offers practical clinical and practice management features and columns specific to retina specialists. In sum, readers will find important peer-reviewed retina articles and the latest findings in techniques and science, as well as informative business and practice management features in one journal.
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