通过监测控制良好的高血压患者血浆中 microRNA-21 的表达水平研究奇奥果胶的降压特性

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Maria Tsota, Panagiota Giardoglou, Evangelia Mentsiou-Nikolaou, Panagiotis Symianakis, Ioanna Panagiota Kalafati, Anastasia-Areti Kyriazopoulou-Korovesi, Lasthenis Angelidakis, Maria Papaioannou, Christina Konstantaki, Hyper-Mastic Consortium, Kimon Stamatelopoulos, George V Dedoussis
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引用次数: 0

摘要

高血压是一种慢性、多因素疾病,导致全球心血管疾病发病率和死亡率居高不下。尽管药物治疗有其优势,但天然产品因其新兴的植物治疗特性而受到科学界的关注。希俄斯胶泥是希腊的一种天然产品,由生物活性化合物组成,可改变微 RNA(调节表达的小分子)的表达。在这项研究中,我们通过评估 miR-21 的水平,研究了希俄斯胶浆的抗高血压特性。在此,我们分析了 57 名高血压患者的血浆样本,这些患者是为了参加 HYPER-MASTIC 研究而被招募的。与正常血压的人相比,患者的 miR-21 明显上调。在对性别和年龄进行调整后,安慰剂组和低剂量组之间以及低剂量组和高剂量组之间的 miR-21 水平的平均变化具有统计学意义。在低剂量组中,干预后的 miR-21 水平与夜间收缩压、脉压和中心收缩平均动脉压呈正相关,而与夜间脉搏波速度呈负相关。我们的研究结果表明,miR-21 对奇奥斯胶原蛋白与夜间血压测量的关系具有潜在的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of Antihypertensive Properties of Chios Mastic via Monitoring microRNA-21 Expression Levels in the Plasma of Well-Controlled Hypertensive Patients.

Hypertension is a chronic, multifactorial disease, leading to high cardiovascular morbidity and mortality globally. Despite the advantages of pharmaceutical treatments, natural products have gained scientific interest due to their emerging phytotherapeutic properties. Chios mastic is a natural Greek product, consisting of bioactive compounds which modify microRNAs' (small, expression-regulating molecules) expression. In this study, we investigated the antihypertensive properties of Chios mastic through the assessment of miR-21 levels. Herein, plasma samples of 57 individuals with hypertension, recruited for the purposes of the HYPER-MASTIC study, were analyzed. This was a clinical trial with Chios mastic supplements in which the patients were divided into groups receiving high and low mastic doses and placebo supplements, respectively. miR-21 was significantly upregulated in patients compared to normotensive individuals. Mean changes in miR-21 levels were statistically significant, after adjusting for sex and age, between the placebo and low-dose group and between the low- and high-dose group. Post-intervention miR-21 levels were positively associated with night-time systolic blood pressure, pulse pressure, and central systolic mean arterial pressure and negatively associated with night-time pulse wave velocity in the low-dose group. Our findings suggest a potential implication of miR-21 in the association of Chios mastic with night-time blood pressure measurements.

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来源期刊
Non-Coding RNA
Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
6.70
自引率
4.70%
发文量
74
审稿时长
10 weeks
期刊介绍: Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.
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