Gwen Zeigler, Cole A Harrington, Nicole Rosendale, Christos Ganos, Valeria Roldan, Anna Pace, Sasha Alick-Lindstrom, Casey Orozco-Poore, Wissam Deeb, Margaret L Hansen, Z Paige L'Erario
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Neurologic Care for Transgender and Gender-Diverse People: A Review of Current Evidence and Clinical Implications.
Purpose of review: To summarize the literature on neurologic care for transgender and gender-diverse (TGD) people and provide implications for clinical practice.
Recent findings: There are limited data on the frequency and management of neurologic conditions among TGD people. TGD people have a higher prevalence of various neurologic conditions compared with cisgender or general population cohorts, including migraine, subjective cognitive decline, sleep disturbances, functional disorders, and cerebrovascular disease. Gender-affirming hormone therapy interacts with commonly prescribed neurologic medications and increases stroke risk among transfeminine people. Sex hormones and sex chromosomes may play a role in neurodegeneration and disability progression in neuroimmunologic diseases. Clitoral reduction surgeries on intersex children can cause neurologic disability and sexual dysfunction in adulthood. Socioeconomic disparities among TGD people contribute to health care barriers.
Summary: Neurologists should consider the unique experiences and health care needs of TGD people in their clinical practice and research protocols.
期刊介绍：
Neurology® Genetics is an online open access journal publishing peer-reviewed reports in the field of neurogenetics. The journal publishes original articles in all areas of neurogenetics including rare and common genetic variations, genotype-phenotype correlations, outlier phenotypes as a result of mutations in known disease genes, and genetic variations with a putative link to diseases. Articles include studies reporting on genetic disease risk, pharmacogenomics, and results of gene-based clinical trials (viral, ASO, etc.). Genetically engineered model systems are not a primary focus of Neurology® Genetics, but studies using model systems for treatment trials, including well-powered studies reporting negative results, are welcome.
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