肿瘤微环境中的谷胱甘肽动态：癌症干细胞和 T 细胞的潜在靶点。

IF 2.5 4区医学 Q3 CELL & TISSUE ENGINEERING

International journal of stem cells Pub Date : 2024-08-30 Epub Date: 2024-06-26 DOI:10.15283/ijsc24060

Youngjun Park, Eui Man Jeong

{"title":"肿瘤微环境中的谷胱甘肽动态：癌症干细胞和 T 细胞的潜在靶点。","authors":"Youngjun Park, Eui Man Jeong","doi":"10.15283/ijsc24060","DOIUrl":null,"url":null,"abstract":"Glutathione (GSH), the main cellular antioxidant, dynamically influences tumor growth, metastasis, and resistance to therapy in the tumor microenvironment (TME), which comprises cancer cells, immune cells, stromal cells, and non-cellular components, including the extracellular matrix, metabolites, hypoxia, and acidity. Cancer stem cells (CSCs) and T cells are minor but significant cell subsets of the TME. GSH dynamics influences the fate of CSCs and T cells. Here, we explored GSH dynamics in CSCs and T cells within the TME, as well as therapeutic approaches that could target these dynamics.","PeriodicalId":14392,"journal":{"name":"International journal of stem cells","volume":" ","pages":"270-283"},"PeriodicalIF":2.5000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361844/pdf/","citationCount":"0","resultStr":"{\"title\":\"Glutathione Dynamics in the Tumor Microenvironment: A Potential Target of Cancer Stem Cells and T Cells.\",\"authors\":\"Youngjun Park, Eui Man Jeong\",\"doi\":\"10.15283/ijsc24060\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Glutathione (GSH), the main cellular antioxidant, dynamically influences tumor growth, metastasis, and resistance to therapy in the tumor microenvironment (TME), which comprises cancer cells, immune cells, stromal cells, and non-cellular components, including the extracellular matrix, metabolites, hypoxia, and acidity. Cancer stem cells (CSCs) and T cells are minor but significant cell subsets of the TME. GSH dynamics influences the fate of CSCs and T cells. Here, we explored GSH dynamics in CSCs and T cells within the TME, as well as therapeutic approaches that could target these dynamics.\",\"PeriodicalId\":14392,\"journal\":{\"name\":\"International journal of stem cells\",\"volume\":\" \",\"pages\":\"270-283\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11361844/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of stem cells\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.15283/ijsc24060\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CELL & TISSUE ENGINEERING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of stem cells","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.15283/ijsc24060","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CELL & TISSUE ENGINEERING","Score":null,"Total":0}

引用次数: 0

摘要

谷胱甘肽（GSH）是主要的细胞抗氧化剂，它能动态地影响肿瘤微环境（TME）中的肿瘤生长、转移和抗药性，TME 由癌细胞、免疫细胞、基质细胞和非细胞成分（包括细胞外基质、代谢产物、缺氧和酸度）组成。癌症干细胞（CSC）和T细胞是TME中次要但重要的细胞亚群。GSH动态影响着CSCs和T细胞的命运。在这里，我们探讨了癌干细胞和T细胞在TME中的GSH动态，以及针对这些动态的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Glutathione Dynamics in the Tumor Microenvironment: A Potential Target of Cancer Stem Cells and T Cells.

Glutathione (GSH), the main cellular antioxidant, dynamically influences tumor growth, metastasis, and resistance to therapy in the tumor microenvironment (TME), which comprises cancer cells, immune cells, stromal cells, and non-cellular components, including the extracellular matrix, metabolites, hypoxia, and acidity. Cancer stem cells (CSCs) and T cells are minor but significant cell subsets of the TME. GSH dynamics influences the fate of CSCs and T cells. Here, we explored GSH dynamics in CSCs and T cells within the TME, as well as therapeutic approaches that could target these dynamics.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

International journal of stem cells Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

5.10

自引率

4.30%

发文量

期刊介绍： International Journal of Stem Cells (Int J Stem Cells), a peer-reviewed open access journal, principally aims to provide a forum for investigators in the field of stem cell biology to present their research findings and share their visions and opinions. Int J Stem Cells covers all aspects of stem cell biology including basic, clinical and translational research on genetics, biochemistry, and physiology of various types of stem cells including embryonic, adult and induced stem cells. Reports on epigenetics, genomics, proteomics, metabolomics of stem cells are welcome as well. Int J Stem Cells also publishes review articles, technical reports and treatise on ethical issues.