短链脂肪酸与种植体周围疾病的相关性:横断面研究

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
Yue Liu, Hu Yang, Pingping Wang, Yilin Shi, Ruiwen Shi, Shengben Zhang, Yajun Zhao, Jing Lan, Shaohua Ge
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SCFAs related to peri‐implant disease were identified by logistic regression and ranked by random forest analysis.ResultsEighty‐six implants were divided into a peri‐implant health group (PIH‐group, 35 implants), peri‐implant mucositis group (PIM‐group, 25 implants), and peri‐implantitis group (PI‐group, 26 implants) according to clinical and radiographic examination results. The PIM‐group had significantly lower formic acid detection rate than the other two groups (<jats:italic>p</jats:italic> &lt; 0.001). The PIM‐group had significantly higher levels of acetic, propionic, and isovaleric acids than the PIH‐group (<jats:italic>p</jats:italic> &lt; 0.05). The PI‐group had significantly higher levels of propionic, butyric, isobutyric, valeric, and isovaleric acids than the PIH‐group (<jats:italic>p</jats:italic> &lt; 0.05). The PI‐group had significantly higher levels of butyric, isobutyric, and isovaleric acids than the PIM‐group (<jats:italic>p</jats:italic> &lt; 0.05). 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引用次数: 0

摘要

背景探讨种植体周围龈沟液(PISF)中的短链脂肪酸(SCFAs)与种植体周围疾病之间的相关性。方法从植入至少5年的种植体中获取PISF样本,并检查种植体周围的临床参数。采用气相色谱-质谱法和高效液相色谱法检测 PISF 中的 SCFAs。SCFAs 与临床参数之间的相关性通过斯皮尔曼相关性进行分析。结果 根据临床和影像学检查结果,将86颗种植体分为种植体周围健康组(PIH组,35颗种植体)、种植体周围粘膜炎组(PIM组,25颗种植体)和种植体周围炎组(PI组,26颗种植体)。PIM 组的甲酸检出率明显低于其他两组(P < 0.001)。PIM 组的乙酸、丙酸和异戊酸水平明显高于 PIH 组(p < 0.05)。PI 组的丙酸、丁酸、异丁酸、戊酸和异戊酸含量明显高于 PIH 组(p < 0.05)。PI 组的丁酸、异丁酸和异戊酸含量明显高于 PIM 组(p < 0.05)。SCFAs(己酸和琥珀酸除外)与临床参数呈显著正相关(p < 0.05)。与种植体周围疾病相关的 SCFAs 排列如下:丁酸、异戊酸、异丁酸、丙酸、乙酸、甲酸和乳酸。结论特定 SCFAs 的升高与种植体周围疾病有关,认识到这种相关性有助于早期识别种植体周围疾病并指导进一步的临床干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Correlation between short‐chain fatty acids and peri‐implant disease: A cross‐sectional study
BackgroundTo explore the correlation between short‐chain fatty acids (SCFAs) in the peri‐implant sulcular fluid (PISF) and peri‐implant diseases.MethodsPISF samples were obtained from implants that have been placed for at least 5 years, and peri‐implant clinical parameters were examined. Gas chromatography‐mass spectrometry and high‐performance liquid chromatography were used to detect SCFAs in PISF. The correlation between SCFAs and clinical parameters was analyzed by Spearman's correlation. SCFAs related to peri‐implant disease were identified by logistic regression and ranked by random forest analysis.ResultsEighty‐six implants were divided into a peri‐implant health group (PIH‐group, 35 implants), peri‐implant mucositis group (PIM‐group, 25 implants), and peri‐implantitis group (PI‐group, 26 implants) according to clinical and radiographic examination results. The PIM‐group had significantly lower formic acid detection rate than the other two groups (p < 0.001). The PIM‐group had significantly higher levels of acetic, propionic, and isovaleric acids than the PIH‐group (p < 0.05). The PI‐group had significantly higher levels of propionic, butyric, isobutyric, valeric, and isovaleric acids than the PIH‐group (p < 0.05). The PI‐group had significantly higher levels of butyric, isobutyric, and isovaleric acids than the PIM‐group (p < 0.05). SCFAs (apart from hexanoic and succinic acids) were significantly and positively correlated with clinical parameters (p < 0.05). SCFAs related to peri‐implant disease were ranked as follows: butyric, isovaleric, isobutyric, propionic, acetic, formic, and lactic acids.ConclusionsElevated specific SCFAs are correlated with peri‐implant disease. Recognition of this correlation may help in early identification of peri‐implant disease and guide further clinical interventions.
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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
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