基于测序的微生物组分析

IF 39.1 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2024-06-25 DOI:10.1038/s41576-024-00746-6

Yishay Pinto, Ami S. Bhatt

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引用次数: 0

摘要

微生物群占据着一系列的生态位，除了具有不同的组成之外，它们还具有不同的功能作用，对农业、环境科学以及人类健康和疾病都有影响。最近的技术和分析进步促进了微生物组的研究，如更便宜、更高通量的 DNA 和 RNA 测序、改进的长读数测序和创新的计算分析方法。这些进步使人们在基因组、转录和翻译层面上对微生物组有了更深入的了解，从而对微生物组的功能和组成有了超越物种层面的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Sequencing-based analysis of microbiomes

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Sequencing-based analysis of microbiomes

Microbiomes occupy a range of niches and, in addition to having diverse compositions, they have varied functional roles that have an impact on agriculture, environmental sciences, and human health and disease. The study of microbiomes has been facilitated by recent technological and analytical advances, such as cheaper and higher-throughput DNA and RNA sequencing, improved long-read sequencing and innovative computational analysis methods. These advances are providing a deeper understanding of microbiomes at the genomic, transcriptional and translational level, generating insights into their function and composition at resolutions beyond the species level. In this Review, Pinto and Bhatt provide an overview of DNA-sequencing and RNA-sequencing approaches that can be used to study the composition, structure, and function of microbiomes and discuss the biological insights they provide.

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

期刊介绍： At Nature Reviews Genetics, our goal is to be the leading source of reviews and commentaries for the scientific communities we serve. We are dedicated to publishing authoritative articles that are easily accessible to our readers. We believe in enhancing our articles with clear and understandable figures, tables, and other display items. Our aim is to provide an unparalleled service to authors, referees, and readers, and we are committed to maximizing the usefulness and impact of each article we publish. Within our journal, we publish a range of content including Research Highlights, Comments, Reviews, and Perspectives that are relevant to geneticists and genomicists. With our broad scope, we ensure that the articles we publish reach the widest possible audience. As part of the Nature Reviews portfolio of journals, we strive to uphold the high standards and reputation associated with this esteemed collection of publications.