tRNA甲基转移酶METTL6需要丝氨酰-tRNA合成酶来实现tRNASer靶向作用

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-06-25 DOI:10.1038/s41594-024-01343-1

引用次数: 0

摘要

RNA 甲基转移酶 METTL6 的过表达会导致增殖增加并诱发癌症。我们的低温电子显微镜（cryo-EM）和生化分析表明，METTL6需要丝氨酸-tRNA合成酶作为辅助因子，才能在丝氨酸tRNA中有效地生成3-甲基胞嘧啶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The tRNA methyltransferase METTL6 requires seryl-tRNA synthetase for tRNASer targeting

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The tRNA methyltransferase METTL6 requires seryl-tRNA synthetase for tRNASer targeting

Overexpression of the RNA methyltransferase METTL6 leads to increased proliferation and promotes cancer. Our cryo-electron microscopy (cryo-EM) and biochemical analyses reveal that METTL6 requires seryl-tRNA synthetase as a cofactor to efficiently generate 3-methyl-cytosine in serine tRNAs.

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.