吸烟对黑色素瘤发病率的影响:系统回顾与荟萃分析。

IF 9.9 1区 医学 Q1 ONCOLOGY
Erica B Friedman, Gabrielle J Williams, Serigne N Lo, John F Thompson
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引用次数: 0

摘要

背景:吸烟与多种癌症的发病有密切关系。因此,多份报告显示吸烟者的黑色素瘤发病率较低,这是一个矛盾的现象。本研究旨在分析所有关于吸烟者相对于非吸烟者黑色素瘤发病率的现有研究:方法:在 MEDLINE 和 Embase 中检索报告吸烟者和从不吸烟者黑色素瘤数据的研究。研究没有设计限制或语言限制。研究结果为吸烟状态与黑色素瘤之间的关系。分析的重点是通过多变量分析得出的吸烟者和从不吸烟者患黑色素瘤的风险,并使用固定效应模型对这些结果进行汇总。使用纽卡斯尔-渥太华工具对偏倚风险进行了评估:49项研究共纳入了59429名黑色素瘤患者。汇总分析表明,当前吸烟者罹患黑色素瘤的风险明显降低,男性也是如此(风险比(RR)为 0.60,95%CI_0.56~0.65,p 解释:当前吸烟者罹患黑色素瘤的风险明显降低:与从不吸烟者相比,目前吸烟者患黑色素瘤的风险明显降低,男性和女性患黑色素瘤的风险分别降低了 40% 和 21%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of smoking on melanoma incidence: a systematic review with meta-analysis.

Background: There is a strong correlation between cigarette smoking and the development of many cancer types. It is therefore paradoxical that multiple reports have suggested a reduced incidence of melanoma in smokers. This study aimed to analyze all existing studies of melanoma incidence in smokers relative to nonsmokers.

Methods: Searches of MEDLINE and Embase were conducted for studies reporting data on melanoma in smokers and never-smokers. No study design limitations or language restrictions were applied. The outcome examined was the association between smoking status and melanoma. Analyses focused on risk of melanoma in smokers and never-smokers generated from multivariable analyses, and these analyses were pooled using a fixed-effects model. Risk of bias was assessed using the Newcastle-Ottawa tool.

Results: Forty-nine studies that included 59 429 patients with melanoma were identified. Pooled analyses showed statistically significant reduced risks of melanoma in male smokers (risk ratio [RR] = 0.60, 95% confidence interval [CI] = 0.56 to 0.65, P < .001) and female smokers (RR = 0.79, 95% CI = 0.73 to 0.86, P < .001). Male former smokers had a 16% reduction in melanoma risk compared with male never-smokers (RR = 0.84, 95% CI = 0.77 to 0.93, P < .001), but no risk reduction was observed in female former smokers (RR = 1.0, 95% CI = 0.92 to 1.08).

Conclusions: Current smokers have a statistically significant reduced risk of developing melanoma compared with never-smokers, with a reduction in melanoma risk of 40% in men and 21% in women.

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来源期刊
CiteScore
17.00
自引率
2.90%
发文量
203
审稿时长
4-8 weeks
期刊介绍: The Journal of the National Cancer Institute is a reputable publication that undergoes a peer-review process. It is available in both print (ISSN: 0027-8874) and online (ISSN: 1460-2105) formats, with 12 issues released annually. The journal's primary aim is to disseminate innovative and important discoveries in the field of cancer research, with specific emphasis on clinical, epidemiologic, behavioral, and health outcomes studies. Authors are encouraged to submit reviews, minireviews, and commentaries. The journal ensures that submitted manuscripts undergo a rigorous and expedited review to publish scientifically and medically significant findings in a timely manner.
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