{"title":"白天过度嗜睡对阻塞性睡眠呼吸暂停患者注意力障碍的影响:一项横断面观察研究。","authors":"Zhiqiang Li, Sijie Cai, Zhijun Wang, Xiao Ding, Qiaojun Wang, Rui Chen","doi":"10.1007/s00405-024-08756-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to examine the relationship between excessive daytime sleepiness (EDS) and attention impairment in Chinese individuals with obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>A total of 1996 OSA patients with an apnea-hypopnea index (AHI) of ≥ 5 events per hour were included in this study. EDS was measured using the Epworth Sleepiness Scale (ESS), while cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA).</p><p><strong>Results: </strong>OSA patients with EDS demonstrated higher body mass index (BMI), comorbidities of hypertension and diabetes, decreased N3 sleep, increased AHI and ODI, as well as lower minimum oxygen saturation. Despite no significant differences in total cognitive scores assessed by MMSE and MoCA, individuals with comorbid sleepiness exhibited more evident attention deficits in the subdomains of MoCA. Stratified analysis indicated that regardless of age, educational level was the primary factor influencing attention in the AHI < =20 group. In the AHI > 20 group, attention impairment in patients younger than 40 remained significantly associated with education level, whereas for individuals aged 40 and above, attention deficits were associated with education level, age, and daytime sleepiness. The interaction analysis indicated that OSA severity modulated the impact of sleepiness on attention in patients aged 40 and above.</p><p><strong>Conclusion: </strong>A significant correlation was observed between EDS and attention deficits in Chinese individuals diagnosed with OSA, with a particular emphasis on patients aged 40 and above. The severity of OSA modulates the impact of sleepiness on attention in patients aged 40 and above.</p>","PeriodicalId":11952,"journal":{"name":"European Archives of Oto-Rhino-Laryngology","volume":" ","pages":"5503-5510"},"PeriodicalIF":1.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of excessive daytime sleepiness on attention impairment in obstructive sleep apnea: a cross-sectional observational study.\",\"authors\":\"Zhiqiang Li, Sijie Cai, Zhijun Wang, Xiao Ding, Qiaojun Wang, Rui Chen\",\"doi\":\"10.1007/s00405-024-08756-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aims to examine the relationship between excessive daytime sleepiness (EDS) and attention impairment in Chinese individuals with obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>A total of 1996 OSA patients with an apnea-hypopnea index (AHI) of ≥ 5 events per hour were included in this study. EDS was measured using the Epworth Sleepiness Scale (ESS), while cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA).</p><p><strong>Results: </strong>OSA patients with EDS demonstrated higher body mass index (BMI), comorbidities of hypertension and diabetes, decreased N3 sleep, increased AHI and ODI, as well as lower minimum oxygen saturation. Despite no significant differences in total cognitive scores assessed by MMSE and MoCA, individuals with comorbid sleepiness exhibited more evident attention deficits in the subdomains of MoCA. Stratified analysis indicated that regardless of age, educational level was the primary factor influencing attention in the AHI < =20 group. In the AHI > 20 group, attention impairment in patients younger than 40 remained significantly associated with education level, whereas for individuals aged 40 and above, attention deficits were associated with education level, age, and daytime sleepiness. The interaction analysis indicated that OSA severity modulated the impact of sleepiness on attention in patients aged 40 and above.</p><p><strong>Conclusion: </strong>A significant correlation was observed between EDS and attention deficits in Chinese individuals diagnosed with OSA, with a particular emphasis on patients aged 40 and above. 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引用次数: 0
摘要
目的:本研究旨在探讨中国阻塞性睡眠呼吸暂停(OSA)患者白天过度嗜睡(EDS)与注意力障碍之间的关系:方法:本研究共纳入1996名呼吸暂停-低通气指数(AHI)≥5次/小时的阻塞性睡眠呼吸暂停患者。使用埃普沃思嗜睡量表(ESS)测量 EDS,使用迷你精神状态检查(MMSE)和蒙特利尔认知评估(MoCA)评估认知功能:结果:患有 EDS 的 OSA 患者体重指数(BMI)较高,合并有高血压和糖尿病,N3 睡眠减少,AHI 和 ODI 增加,最低血氧饱和度降低。尽管MMSE和MoCA评估的认知总分没有明显差异,但合并嗜睡的患者在MoCA的子域中表现出更明显的注意力缺陷。分层分析表明,无论年龄如何,教育水平都是影响 AHI 20 组患者注意力的主要因素,40 岁以下患者的注意力障碍仍与教育水平显著相关,而对于 40 岁及以上的患者,注意力障碍则与教育水平、年龄和白天嗜睡相关。交互分析表明,OSA 的严重程度调节了嗜睡对 40 岁及以上患者注意力的影响:结论:在被诊断患有 OSA 的中国人中,观察到 EDS 与注意力缺陷之间存在明显的相关性,尤其是 40 岁及以上的患者。OSA的严重程度会调节嗜睡对40岁及以上患者注意力的影响。
Impact of excessive daytime sleepiness on attention impairment in obstructive sleep apnea: a cross-sectional observational study.
Purpose: This study aims to examine the relationship between excessive daytime sleepiness (EDS) and attention impairment in Chinese individuals with obstructive sleep apnea (OSA).
Methods: A total of 1996 OSA patients with an apnea-hypopnea index (AHI) of ≥ 5 events per hour were included in this study. EDS was measured using the Epworth Sleepiness Scale (ESS), while cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA).
Results: OSA patients with EDS demonstrated higher body mass index (BMI), comorbidities of hypertension and diabetes, decreased N3 sleep, increased AHI and ODI, as well as lower minimum oxygen saturation. Despite no significant differences in total cognitive scores assessed by MMSE and MoCA, individuals with comorbid sleepiness exhibited more evident attention deficits in the subdomains of MoCA. Stratified analysis indicated that regardless of age, educational level was the primary factor influencing attention in the AHI < =20 group. In the AHI > 20 group, attention impairment in patients younger than 40 remained significantly associated with education level, whereas for individuals aged 40 and above, attention deficits were associated with education level, age, and daytime sleepiness. The interaction analysis indicated that OSA severity modulated the impact of sleepiness on attention in patients aged 40 and above.
Conclusion: A significant correlation was observed between EDS and attention deficits in Chinese individuals diagnosed with OSA, with a particular emphasis on patients aged 40 and above. The severity of OSA modulates the impact of sleepiness on attention in patients aged 40 and above.
期刊介绍:
Official Journal of
European Union of Medical Specialists – ORL Section and Board
Official Journal of Confederation of European Oto-Rhino-Laryngology Head and Neck Surgery
"European Archives of Oto-Rhino-Laryngology" publishes original clinical reports and clinically relevant experimental studies, as well as short communications presenting new results of special interest. With peer review by a respected international editorial board and prompt English-language publication, the journal provides rapid dissemination of information by authors from around the world. This particular feature makes it the journal of choice for readers who want to be informed about the continuing state of the art concerning basic sciences and the diagnosis and management of diseases of the head and neck on an international level.
European Archives of Oto-Rhino-Laryngology was founded in 1864 as "Archiv für Ohrenheilkunde" by A. von Tröltsch, A. Politzer and H. Schwartze.