Amit Kumar Chatterjee, Pandeep Kaur, Davood Bava, Akarshan Gupta, Amit Kumar, Rakesh Kumar
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Anti-A and anti-B titers were determined using the Conventional Tube Technique (CTT). Statistical analysis assessed correlations between high titers and demographic factors.</p><p><strong>Results: </strong>The majority of participants were young males (98.8%). Prevalence of high titers for IgM anti-A was 12.2% and IgG anti-A was 2.5%. For anti-B, IgM titers were 2.3% and IgG titers were 0.2%. The prevalence of dangerous O was found to be 14.1%, while 3.52% and 10.5% of A and B blood group donors were found to have high titers, respectively. Factors associated with high titers included female gender, vegetarian diet, age <30 years, and O blood group.</p><p><strong>Conclusion: </strong>The study sheds additional light and provides supplementary information regarding the prevalence and correlation of high anti-A and anti-B titers among O, A and B blood donors. Understanding these factors is crucial for optimizing transfusion safety protocols, including selective screening of platelet units and tailored transfusion strategies based on donor characteristics.</p>","PeriodicalId":94255,"journal":{"name":"Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anti-A and anti-B titers in A, B and O whole blood donors: Beyond \\\"dangerous O\\\".\",\"authors\":\"Amit Kumar Chatterjee, Pandeep Kaur, Davood Bava, Akarshan Gupta, Amit Kumar, Rakesh Kumar\",\"doi\":\"10.1016/j.tracli.2024.06.007\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>Hemolytic transfusion reactions (HTRs) pose significant risks in transfused patients, with anti-A and anti-B antibodies in donor plasma being potential contributing factors. 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引用次数: 0
摘要
背景和目的:溶血性输血反应(HTR)对输血患者构成重大风险,供体血浆中的抗 A 和抗 B 抗体是潜在的诱因。尽管成分制备技术不断进步,但溶血性输血反应仍是一个令人担忧的问题,尤其是无细胞血浆来源的血小板。本研究旨在确定高抗A和抗B滴度在A、B和O型血献血者中的流行率,并探讨与高滴度相关的因素:这项横断面观察研究历时 18 个月,从印度西部一家三级医疗教学医院招募了 978 名参与者。采用传统试管技术(CTT)测定抗 A 和抗 B 滴度。统计分析评估了高滴度与人口统计学因素之间的相关性:结果:大多数参与者为年轻男性(98.8%)。高滴度 IgM 抗 A 为 12.2%,IgG 抗 A 为 2.5%。抗 B 的 IgM 滴度为 2.3%,IgG 滴度为 0.2%。危险 O 型血的流行率为 14.1%,而 A 型和 B 型血献血者中分别有 3.52% 和 10.5% 滴度较高。与高滴度相关的因素包括女性性别、素食、年龄 结论:这项研究揭示了 O、A 和 B 型献血者中高抗 A 和抗 B 滴度的流行率和相关性,并提供了补充信息。了解这些因素对于优化输血安全方案至关重要,包括血小板单位的选择性筛查和基于献血者特征的定制输血策略。
Anti-A and anti-B titers in A, B and O whole blood donors: Beyond "dangerous O".
Background and objectives: Hemolytic transfusion reactions (HTRs) pose significant risks in transfused patients, with anti-A and anti-B antibodies in donor plasma being potential contributing factors. Despite advancements in component preparation, HTRs remain a concern, particularly with apheresis-derived platelets. This study aimed to determine the prevalence of high anti-A and anti-B titers among A, B, and O blood group donors and to explore factors associated with high titers.
Materials and methods: A cross-sectional observational study was conducted over 18 months, enrolling 978 participants from a tertiary care teaching hospital in Western India. Anti-A and anti-B titers were determined using the Conventional Tube Technique (CTT). Statistical analysis assessed correlations between high titers and demographic factors.
Results: The majority of participants were young males (98.8%). Prevalence of high titers for IgM anti-A was 12.2% and IgG anti-A was 2.5%. For anti-B, IgM titers were 2.3% and IgG titers were 0.2%. The prevalence of dangerous O was found to be 14.1%, while 3.52% and 10.5% of A and B blood group donors were found to have high titers, respectively. Factors associated with high titers included female gender, vegetarian diet, age <30 years, and O blood group.
Conclusion: The study sheds additional light and provides supplementary information regarding the prevalence and correlation of high anti-A and anti-B titers among O, A and B blood donors. Understanding these factors is crucial for optimizing transfusion safety protocols, including selective screening of platelet units and tailored transfusion strategies based on donor characteristics.