Benjamin N Gantner, Flavio R Palma, Cezar Kayzuka, Riccardo Lacchini, Daniel R Foltz, Vadim Backman, Neil Kelleher, Ali Shilatifard, Marcelo G Bonini
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引用次数: 0
摘要
有氧呼吸的出现创造了前所未有的生物能量优势,同时也提出了保护关键遗传信息免受氧化代谢反应性副产物(即活性氧)影响的要求。组蛋白的进化满足了保护 DNA 免受这些潜在破坏性毒素侵害的需要,同时也提供了压缩和构建庞大真核生物基因组的手段。迄今为止,已经证明了几种与新陈代谢相关的组蛋白翻译后修饰(PTM)可以调节染色质结构和基因表达。然而,新陈代谢产生的 ROS 是否以及如何通过 PTM 调节染色质的适应性重塑仍相对缺乏研究。在此,我们回顾了 ROS 与组蛋白相互作用的新机理及其对基因表达调控、细胞可塑性和行为控制的影响。
Histone oxidation as a new mechanism of metabolic control over gene expression.
The emergence of aerobic respiration created unprecedented bioenergetic advantages, while imposing the need to protect critical genetic information from reactive byproducts of oxidative metabolism (i.e., reactive oxygen species, ROS). The evolution of histone proteins fulfilled the need to shield DNA from these potentially damaging toxins, while providing the means to compact and structure massive eukaryotic genomes. To date, several metabolism-linked histone post-translational modifications (PTMs) have been shown to regulate chromatin structure and gene expression. However, whether and how PTMs enacted by metabolically produced ROS regulate adaptive chromatin remodeling remain relatively unexplored. Here, we review novel mechanistic insights into the interactions of ROS with histones and their consequences for the control of gene expression regulation, cellular plasticity, and behavior.
期刊介绍:
Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology.
Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.