胶原蛋白生物刺激剂可改善光老化色素沉着

IF 3.5 3区 医学 Q1 DERMATOLOGY
Jin Cheol Kim, Dong Chan Kim, Hyoung Soo Park, Suk Bae Seo, Hee Young Kang
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引用次数: 0

摘要

老年性白斑和黄褐斑等光老化色素沉着病症表现为表皮黑色素生成活性和真皮异常,包括胶原蛋白降解。针对光老化色素沉着,建议采用直接作用于黑色素细胞的皮肤美白疗法的真皮年轻化策略。本研究探讨了胶原蛋白生物刺激是否能使光老化皮肤变白。研究人员对 40 名患有面部黄褐斑和老年性白斑的受试者进行了分脸临床试验。受试者的一侧面部接受聚二氯丙烯酸(PDLLA)治疗,而对侧面部则接受生理盐水治疗作为对照。治疗结束后每月进行一次评估,最长持续 3 个月。色素沉着的评估采用色度计测量的 L* 值和研究人员的总体评估分数(IGA)。受试者报告了整体皮肤质量的不同结果,包括色素沉着、皱纹和弹性。皮肤活组织切片在治疗前和治疗结束 4 周后采集。进行了 Fontana-Masson、Masson-Trichrome 和 Verhoeff-van Gieson 染色以及成纤维细胞特异性蛋白 1(FSP1)免疫染色。PDLLA 治疗在受试者完成治疗 8 周后,L* 值和 IGA 评分均有明显改善。这些改善持续了 12 周的评估期。在整个评估期间,受试者的色素沉着、皱纹严重程度和弹性都有了大幅改善。Fontana-Masson 染色显示,与基线值相比,注射 PDLLA 后色素沉着明显减少。FSP1 的免疫原性增强,胶原蛋白和弹力纤维染色增加。这项研究表明,使用胶原蛋白生物刺激剂可明显改善光老化色素沉着和胶原蛋白的生成。因此,胶原蛋白生物刺激剂是解决与黄褐斑和老年性白斑相关的光老化症状的一种很有前景的治疗方法。(ClinicalTrials.gov Identifier:NCT05913102)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A collagen biostimulator improves photoaging pigmentation

Photoaging pigmentation conditions such as senile lentigo and melasma show epidermal melanogenic activity and dermal abnormalities, including collagen degradation. A dermal rejuvenation strategy with skin-lightening therapy directly acting on melanocytes is suggested for photoaging pigmentation. This study investigates whether collagen biostimulation can result in skin lightening of photoaging skin. A split-face clinical trial was conducted, involving 40 subjects with facial melasma and senile lentigo. Subjects received a poly-DL-lactic acid (PDLLA) treatment on one side of their face, whereas the contralateral side received a treatment of normal saline as a control. Assessments were scheduled every month after completing treatments for up to 3 months. Pigmentation was evaluated using the L* value as measured with a chromameter and by investigator global assessment scores (IGA). Subjects reported different outcomes in terms of overall skin quality, including pigmentation, wrinkles and elasticity. Skin biopsies were obtained before the treatment and 4 weeks after completing the treatment. Fontana-Masson, Masson-Trichrome and Verhoeff-van Gieson staining, and fibroblast-specific protein 1 (FSP1) immunostaining were conducted. The PDLLA treatment demonstrated significant improvements in the L* values and IGA scores from 8 weeks after the subject completed their treatments. These improvements were sustained over a 12-week assessment period. The subjects reported substantial reductions in both pigmentation and wrinkle severity and elasticity throughout the assessment period. Fontana-Masson staining showed a marked decrease in pigmentation upon a PDLLA injection compared to the baseline values. Increased immunogenicity of FSP1 and increases in collagen and elastic fibre staining were observed. This study demonstrated remarkable improvements in photoaging pigmentation along with collagen production with a collagen biostimulator. Thus, collagen biostimulators represent a promising therapeutic approach for addressing photoaging signs associated with melasma and senile lentigo. (ClinicalTrials.gov Identifier: NCT05913102).

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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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